Adipose Tissue Clinical Trial
Official title:
The Influence Of GIP (Glucose-Dependent Insulinotropic Polypeptide) Infusion On Hormone Sensitive Lipase, Lipoprotein Lipase And Adipokine Expression In Human Subcutaneous Adipose Tissue: An In Vivo Study
Study part-1
GIP (glucose-dependent insulinotropic polypeptide) is one of the two main incretin hormones
secreted by specialized cells of the gastrointestinal tract in response to ingestion of
nutrients. Data emerging from studies in animal models and cultured human fat cells support
a physiological role for GIP in the adipose tissue metabolism which may contribute to the
pathogenesis of obesity.
The proposed study will shed more light on the interactions between gut hormones and adipose
tissue. For this pilot study, male subjects fulfilling the inclusion criteria will be given
GIP or placebo infusions in a randomized manner. Fat tissue biopsies will be obtained from
all subjects during both visits, once in the basal state (before the start of the
peptide/placebo infusion) and then repeated at the end of the period of infusion.
Study part-2
Surgery represents the most effective therapeutic modality for morbid obesity. Resolution of
type 2 diabetes mellitus (T2DM) has been consistently observed as an additional benefit of
surgical treatment of obesity. The mechanisms underlying the dramatic effects of surgery on
insulin sensitivity and β-cell function are poorly understood. Bariatric surgery (gastric
bypass) promotes changes in the enteroendocrine system as a result of nutrient diversion
from the physiological intestinal routes with subsequent profound modification of gut
hormone secretion
We hypothesize that restoration of GIP action after bariatric procedures plays a cardinal
role in the improvement and/or restoration of diabetes, we propose to study patients (both
sex)with morbid obesity and T2DM within 3 months after their surgery. Their responses will
be compared to those of BMI matched control subjects with normal glucose tolerance
Status | Recruiting |
Enrollment | 12 |
Est. completion date | December 2012 |
Est. primary completion date | December 2012 |
Accepts healthy volunteers | No |
Gender | Male |
Age group | 18 Years to 75 Years |
Eligibility |
Inclusion Criteria: - Lean (BMI 20-25 kg/m2) subjects with normal glucose tolerance - Obese (BMI >30 kg/m2) subjects also with normal glucose tolerance. - Obese with impaired glucose tolerance - Obese with diet controlled diabetes mellitus - Morbid obesity, type diabetes and post bariatric surgery (study part 2) Exclusion Criteria: - History of severe cardiac, hepatic or renal disease - Thyroid dysfunction (hyper-or hypothyroidism), or other endocrine disturbance (acromegaly, growth hormone deficiency, hypoadrenalism or cortisol overproduction) - Current malignant disease - Known alcohol misuse - Major psychiatric disease (including current use of antidepressants) - History of major eating disorder (anorexia or bulimia nervosa) |
Allocation: Randomized, Endpoint Classification: Pharmacodynamics Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Basic Science
Country | Name | City | State |
---|---|---|---|
United Kingdom | University Hospital Aintree | Liverpool |
Lead Sponsor | Collaborator |
---|---|
Aintree University Hospitals NHS Foundation Trust |
United Kingdom,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | To measure Lipoprotein lipase (LPL) and Hormone sensitive Lipase (HSL) activity in adipose tissue | Before and after 4 hours of infusion | No | |
Secondary | To determine the role of GIP in adipocytokine gene expression and secretion from human subcutaneous adipose tissue | Baseline and after 4 hours of continuous infusion | No |
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT01345591 -
A Study to Evaluate the Results of Facial Soft Tissue Reconstruction in Patients Who Have Suffered Traumatic Injury
|
N/A | |
Recruiting |
NCT03675464 -
Study of Human Adipose Tissue (LOSHAT)
|
||
Completed |
NCT03350997 -
Effects of Exercise and Energy Balance on 24-hour Blood Glucose Control
|
N/A | |
Terminated |
NCT05128318 -
TuLip : Role of the Tumor Environment in Cancer-related Fat Loss
|
N/A | |
Recruiting |
NCT06169670 -
Autologous Fat Grafting to the Face With Use of the Viality™ System
|
N/A | |
Completed |
NCT03757767 -
The Fasting Study - Unraveling the Mechanistic Effects of Prolonged Fasting in Humans.
|
N/A | |
Completed |
NCT03314506 -
Adipose Tissue Cellular Response to Exercise in Healthy Humans
|
N/A | |
Recruiting |
NCT01605578 -
Description of Abdominal and Gluteo-femoral Subcutaneous Adipose Tissue Cell Population in Women - GLUTAB
|
N/A | |
Completed |
NCT04679246 -
Participatory Intervention to Improve Nutrition and Physical Activity in Schoolchildren From Acatlán de Juárez, Jalisco
|
N/A | |
Recruiting |
NCT05766566 -
Treatment of Perianal Fistulas in Crohn's Disease With Autologous Microfragmented Adipose Tissue With the Lipogems System
|
||
Recruiting |
NCT04352244 -
The Physiology of Human Brown Adipose Tissue
|
||
Recruiting |
NCT06304506 -
Effect of Obesity on Extracellular Matrix Composition
|
N/A | |
Completed |
NCT04834609 -
Adipose Derived Mesenchymal Stem Cell Characteristics in Anal Fistulas
|
N/A | |
Completed |
NCT00850629 -
Hormonal Regulation of Body Weight Maintenance
|
N/A | |
Terminated |
NCT03396978 -
The Influence of Gonadal Hormone Suppression on Adipocyte Lineage and the Microbiome
|
N/A | |
Completed |
NCT04797988 -
Eon® Flanks Safety Clinical Study Protocol
|
N/A | |
Active, not recruiting |
NCT06431230 -
School-based HIIT and Dose-Response Effects
|
N/A | |
Completed |
NCT02569112 -
Evaluation of CoolSculpt Combining Venus Legacy Technology for Enhanced Results in Fat Reduction & Laxity of the Flanks
|
N/A | |
Completed |
NCT01822301 -
Structural Fat Grafting for Craniofacial Trauma: Repeat Fat Grafting Injection-5 Subject Cohort
|
N/A | |
Terminated |
NCT01564524 -
Effect of Concentrating Endogenous Stromal Cells in the Fat Graft
|
N/A |