Prevalence of Attention Deficit Hyperactivity Disorder and Its Comorbidities

ADHD Clinical Trial

Official title:

Prevalence Study of Attention Deficit Hyperactivity Disorder and Its Comorbidities Among a Sample of Primary School Students in New Valley Governorate

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT06146595
• Other study ID #: ADHD and its comorbidity
• Status: Not yet recruiting
• Start date: February 1, 2024
• Est. completion date: November 1, 2025

Study information

• Verified date: November 2023
• Source: Assiut University
• Contact: Mahmoud Mohamed, assistant lecturer
• Phone: 00201099636567
• Email: sirdabash1993[@]gmail.com
• Is FDA regulated: No
• Study type: Observational [Patient Registry]

Clinical Trial Summary

Estimate the prevalence of attention deficit hyperactivity disorder and comorbid psychiatric disorder among primary school students in New Valley governorate.

Description:

ADHD (attention deficit hyperactivity disorder) is a common neurodevelopmental disorder characterized by hyperactivity, impulsivity, and inattention. Its prevalence ranges between 5.9 and 7.1% worldwide. Etiology of ADHD included combinations of genetic, neurological, and environmental factors. ADHD is more often a complex disorder with a high rate of associated comorbid conditions. Comorbid conditions are prevalent among people with ADHD and increase its burden and complexity of management. Children with ADHD are at a higher risk than children without ADHD for developing other psychiatric disorders. Most children with ADHD also have at least one comorbid condition, the presence of which contributes to poorer long-term outcomes. The pattern of comorbidities is influenced by age and sex; externalizing disorders are more common in younger ages and male participants, in contrast, internalizing disorders are more prevalent among older ages and female participants. Comorbidity involving ADHD and learning disorders is frequent, ranging from 25 to 40%. Other disorders likely to co-occur with ADHD are: bipolar disorders (11-75%), tic disorders (20%), obsessive compulsive disorders (6-15%). Children with ADHD may show several motor problems: longer and more variable reaction times, increased variability in speed and less accurate response reengagement, and impaired orienting responses, and increased number of responses with very long reaction times. Neurological soft sign have been associated with inattention and behavior difficulties for decades. Some researchers argue that these signs should be included in the diagnosis of ADHD.

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 200
• Est. completion date: November 1, 2025
• Est. primary completion date: September 1, 2025
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 6 Years to 17 Years

Eligibility

Inclusion Criteria:

Age: 6-17 years. Sex: both sexes will be included in the study. Exclusion Criteria: Age: less than 6 years or more than 17 years. Patients with major neurological deficits, cerebral palsy. Patient who refusing to participate in the study or their caregiver refusing to give informed consent. Mentally retarded children.

Related Conditions & MeSH terms

• ADHD
• Attention Deficit Disorder with Hyperactivity

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Assiut University

References & Publications (11)

Becker SP, Langberg JM, Evans SW. Sleep problems predict comorbid externalizing behaviors and depression in young adolescents with attention-deficit/hyperactivity disorder. Eur Child Adolesc Psychiatry. 2015 Aug;24(8):897-907. doi: 10.1007/s00787-014-0636 — View Citation

Belanger SA, Andrews D, Gray C, Korczak D. ADHD in children and youth: Part 1-Etiology, diagnosis, and comorbidity. Paediatr Child Health. 2018 Nov;23(7):447-453. doi: 10.1093/pch/pxy109. Epub 2018 Oct 24. — View Citation

Cardo E, Casanovas S, de la Banda G, Servera M. [Soft neurological signs: are they of any value in the assessment and diagnosis of attention deficit hyperactivity disorder?]. Rev Neurol. 2008;46 Suppl 1:S51-4. Spanish. — View Citation

Gillberg C, Gillberg IC, Rasmussen P, Kadesjo B, Soderstrom H, Rastam M, Johnson M, Rothenberger A, Niklasson L. Co-existing disorders in ADHD -- implications for diagnosis and intervention. Eur Child Adolesc Psychiatry. 2004;13 Suppl 1:I80-92. doi: 10.10 — View Citation

Jensen CM, Steinhausen HC. Comorbid mental disorders in children and adolescents with attention-deficit/hyperactivity disorder in a large nationwide study. Atten Defic Hyperact Disord. 2015 Mar;7(1):27-38. doi: 10.1007/s12402-014-0142-1. Epub 2014 Jun 19. — View Citation

Johansen EB, Aase H, Meyer A, Sagvolden T. Attention-deficit/hyperactivity disorder (ADHD) behaviour explained by dysfunctioning reinforcement and extinction processes. Behav Brain Res. 2002 Mar 10;130(1-2):37-45. doi: 10.1016/s0166-4328(01)00434-x. — View Citation

Mohammadi MR, Zarafshan H, Khaleghi A, Ahmadi N, Hooshyari Z, Mostafavi SA, Ahmadi A, Alavi SS, Shakiba A, Salmanian M. Prevalence of ADHD and Its Comorbidities in a Population-Based Sample. J Atten Disord. 2021 Jun;25(8):1058-1067. doi: 10.1177/108705471 — View Citation

Spencer TJ, Biederman J, Mick E. Attention-deficit/hyperactivity disorder: diagnosis, lifespan, comorbidities, and neurobiology. J Pediatr Psychol. 2007 Jul;32(6):631-42. doi: 10.1093/jpepsy/jsm005. Epub 2007 Jun 7. — View Citation

Tung I, Li JJ, Meza JI, Jezior KL, Kianmahd JS, Hentschel PG, O'Neil PM, Lee SS. Patterns of Comorbidity Among Girls With ADHD: A Meta-analysis. Pediatrics. 2016 Oct;138(4):e20160430. doi: 10.1542/peds.2016-0430. Epub 2016 Sep 21. — View Citation

Willcutt EG. The prevalence of DSM-IV attention-deficit/hyperactivity disorder: a meta-analytic review. Neurotherapeutics. 2012 Jul;9(3):490-9. doi: 10.1007/s13311-012-0135-8. — View Citation

Yoshimasu K, Barbaresi WJ, Colligan RC, Voigt RG, Killian JM, Weaver AL, Katusic SK. Childhood ADHD is strongly associated with a broad range of psychiatric disorders during adolescence: a population-based birth cohort study. J Child Psychol Psychiatry. 2 — View Citation

* Note: There are 11 references in all — Click here to view all references

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Detect the prevalence of attention deficit hyperactivity disorder among primary school students in New Valley governorate	the child and his parents will be subjected to special psychiatric interview sheet designed at child psychiatric unit at Assiut university hospital for collecting detailed psychiatric history of the child and assessment of the child through a detailed interview including mental state examination and neurological examination.also the child will be subjected to Conner's Parent Rating Scale-revised (L).	Baseline
Secondary	Detect comorbid psychiatric disorder among ADHD primary school student in New Valley governorate.	the child will be subjected to Child behavior checklist (CBCL), parent form	Baseline