Investigation of Psychophysiological Correlation of Aggression and Response to Aversive Stimuli

ADHD Clinical Trial

Official title:

Investigation of Psychophysiological Correlation of Aggression and Response to Aversive Stimuli

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03725371
• Other study ID #: YNC-SASSI-Quanti-1
• Status: Completed
• Start date: August 2011
• Est. completion date: August 2015

Study information

• Verified date: October 2018
• Source: Yale-NUS College
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational [Patient Registry]

Clinical Trial Summary

This study investigates the psychophysiological correlations of aggression and response to aversive stimuli in a population of 133 children clinically diagnosed with conduct disorder (CD) and/or attention-deficit/hyperactivity disorder (ADHD). Data was gathered about participants' level of aggression through the Reactive-Proactive Aggression Questionnaire (RPQ). The stimuli that were presented to the participants included 1) a loud sound, 2) threatening photographs from the International Affective Picture System (IAPS), and 3) the Trier Social Stress Task (TSST). Participants' psychophysiological features of heart rate and galvanic skin conductance were measured and analyzed in relation to their RPQ scores and clinical diagnosis.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 133
• Est. completion date: August 2015
• Est. primary completion date: August 2015
• Accepts healthy volunteers: No
• Gender: All
• Age group: 7 Years to 16 Years

Eligibility

Inclusion Criteria:

1. Subjects between ages 7 and 16 years

2. Subjects who fulfil all criteria for a DSM-IV diagnosis of ADHD, conduct disorder, or oppositional defiant disorder

3. Subjects with willingness to participate in a randomized, double-blind controlled trial

4. Subjects with complete written, informed parental consent and child assent

5. Subjects with IQ of 70 or more

Exclusion Criteria:

1. Subjects who have IQ in the below 70

2. Subjects who are younger than 7 years old or older than 16 years old

3. Those without written parental consent

4. Those with brain pathology such as serious head injury, epilepsy, etc.

Related Conditions & MeSH terms

• ADHD
• Aggression
• Attention Deficit and Disruptive Behavior Disorders
• Conduct Disorder
• Disease
• Oppositional Defiant Disorder

Intervention

Other:
• No intervention was administered for the purpose of this study.
No intervention was administered for the purpose of this study. Observations were carried out for all participants.

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Yale-NUS College

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Heart Rate	For Trier Social Stress Task	7 minutes
Primary	Skin Conductance Response	For loud sound	4 minutes
Primary	Skin Conductance Response	For threatening photograph	4 minutes