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Basic and Clinical Research on Attention Deficit Hyperactivity Disorder (ADHD)

ADHD Clinical Trial

Official title:
Dose Response Pharmacogenetic Study of ADHD

Clinical Trial Summary

Children between 6-17 are evaluated for ADHD and and a blood sample is obtained for DNA extraction. If eligible, they participate in a 4 week, double blind, placebo controlled trial with weekly switches. In randomized order, children receive 18, 36, 54 mg. OROS methylphenidate and placebo. Each week, parent report measures, clinical interviews, and safety assessments are conducted.

Hypothesis: Efficacy and adverse events will be dose dependent. Dopamine Transporter Genotype will predict response

Clinical Trial Description

n/a

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment

Related Conditions & MeSH terms

  • ADHD
  • Attention Deficit Disorder with Hyperactivity
Clinical Trial Details
NCT number NCT00663442
Study type Interventional
Source University of Illinois at Chicago
Contact
Status Completed
Phase Phase 4
Start date December 1999
Completion date November 2004
View Details
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