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ADHD clinical trials

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NCT ID: NCT05713331 Terminated - ADHD Clinical Trials

Web-based Professional Development for SMHPs in Evidence-Based Practices for Attention and Behavior Challenges

CLS-R
Start date: September 1, 2017
Phase: N/A
Study type: Interventional

This study develops a web-based PD (CLS-R) to provide SSWs with remote training in EBPs for attention and behavior problems. CLS-R is designed to be usable, feasible, portable, accessible, and acceptable - ingredients which have been identified as necessary for the sustainability of school-based programs. The study evaluates the usability, feasibility, acceptability, fidelity of implementation, and preliminary effects on student outcomes.

NCT ID: NCT05219370 Terminated - ADHD Clinical Trials

Treatment With Cannabis Oil Containing CBD, THC, CBDV or CBG vs. Placebo of Persons With ADHD

Start date: July 31, 2022
Phase: Phase 2
Study type: Interventional

ADHD is the most frequent neuro-developmental disorder in childhood and often continues into adolescence and adulthood. Indicated drug treatments for ADHD fall into 2 categories: stimulants (such as methylphenidate and amphetamines) and non-stimulants (such as atomoxetine, guanfacine and clonidine) but some persons cannot tolerate their secondary effects or find them non-effective. In the last decade, medical cannabis products have been researched as possible treatment for neurological and mental diseases such as: Post trauma disorder (PTD), autism (ASD), epilepsy, fibromyalgia (FM) and more. Data on the effects of cannabidiol rich cannabis extract use for ADHD seems promising but is still limited. The aim of this study is to investigate if oral cannabinoids given to adults with ADHD affect the symptoms of the disorder. The main objectives of the study are: 1) to characterize the effects of treatment with cannabis oil on symptoms of ADHD; 2) to compare safety and efficacy of cannabis oil products with different CBD,Cannabidivarin (CBDV), cannabigerol (CBG) and THC ratio; 3) and to measure endocannabinoids, THC and CBD and metabolites levels in the blood of the participants. In this study, participants diagnosed with ADHD will be treated with canabidiol-rich cannabis oil and will follow up weekly during approx.1 month (the study period). Blood tests will be performed before and after treatment. Blood tests include blood count, blood chemistry, hormones profile, phyto- and endo- cannabinoids and their metabolites. Test of Variables of Attention test (TOVA) will be administrated before and after treatment

NCT ID: NCT04386811 Terminated - ADHD Clinical Trials

Vitamin D as a Therapeutic Adjunct in the Stimulant Treatment of ADHD: a Proof-of-concept Tele-health Study of Stimulant-induced Improvement in Neurocognitive Functioning.

Start date: August 5, 2020
Phase: Phase 1
Study type: Interventional

The purpose of this study is to assess vitamin D as a therapeutic adjunct in the stimulant treatment of ADHD.

NCT ID: NCT02599571 Terminated - ADHD Clinical Trials

Effects of Nicotine Reduction on Smoking Behavior in ADHD Smokers

ADHDenic
Start date: March 30, 2016
Phase: N/A
Study type: Interventional

The purpose of this study is to investigate the impact of different nicotine levels in cigarettes with individuals who have ADHD.

NCT ID: NCT02271880 Terminated - ADHD Clinical Trials

Improving Medication Adherence in ADHD Adolescents

Start date: September 2015
Phase: N/A
Study type: Interventional

Investigates whether a family-based intervention for adolescents with Attention Deficit Hyperactivity Disorder (ADHD) will improve adherence to prescribed medication regimen in adolescents with history of medication nonadherence.

NCT ID: NCT01777048 Terminated - ADHD Clinical Trials

Omega-3 Fatty Acids Supplementation in ADHD

Start date: April 2013
Phase: Phase 3
Study type: Interventional

The overarching aim of the proposed study is to assess whether omega-3 fatty acids supplementation can augment the effects of methylphenidate in children with ADHD. The investigators hypothesized that omega-3 fatty acids supplementation will be associated with improved ADHD symptoms.

NCT ID: NCT01733680 Terminated - ADHD Clinical Trials

Amiloride Hydrochloride as an Effective Treatment for ADHD

Start date: September 2012
Phase: Early Phase 1
Study type: Interventional

The investigators are proposing to test a medication derived from our prior studies of the gene SLC9A9. This one gene makes NHE proteins that control how we learn and remember items, which is impaired in ADHD and may cause an inability to plan, prioritize, self-monitor,inhibit, initiate, self-correct, or control one's behavior. The investigators now propose to investigate the therapeutic utility of an NHE inhibitor, amiloride hydrochloride, for the treatment of attention deficit hyperactivity disorder (ADHD) in medication-naïve adults with ADHD.

NCT ID: NCT01721330 Terminated - Clinical trials for Attention Deficit Hyperactivity Disorder

A Double-Blind Comparison of Naltrexone and Placebo in Adults With Attention Deficit Hyperactivity Disorder

Start date: November 2012
Phase: Phase 4
Study type: Interventional

The primary aim of this study is to assess whether naltrexone as a monotherapy is effective in treating ADHD in adults. Medications that increase dopamine are often effective treatments for ADHD. Since naltrexone is a kappa opioid receptor antagonist, it increases dopamine in the brain. The investigators predict that naltrexone as a monotherapy will be effective for ADHD symptoms in adults with ADHD. The investigators also plan to assess the effects of naltrexone on dopamine as measured by changes in serum prolactin. The investigators predict that naltrexone will increase dopamine as indexed by decreases in serum prolactin. This study will be a six-week, double-blind, placebo-controlled pilot study with adults 18-55 years of age with ADHD.

NCT ID: NCT01340690 Terminated - ADHD Clinical Trials

Efficacy Study of Polyunsaturated Fatty Acids in Children and Adolescents With Attention Deficit/ Hyperactivity Disorder

PAD
Start date: March 8, 2011
Phase: Phase 3
Study type: Interventional

This study will determine the nutritional efficacy of Polyunsaturated Fatty Acids (PUFAs) in combination with zinc and magnesium, in children and adolescents diagnosed with Attention Deficit/ Hyperactivity Disorder (ADHD). The nutritional efficacy has to be proven in agreement with the German "Verordnung über Diätetische Lebensmittel (DiätV)" and the corresponding European Directive 1999/21/EC. This objective is reached by performing a placebo-controlled supplementation study with a main efficacy criterion which is also being used in pivotal studies of stimulant and non-stimulant drugs, i.e. the treatment differences between final visit and baseline in the Attention Deficit Hyperactivity Disorder Rating Scale, Parent Version IV (ADHDRS-IV).

NCT ID: NCT00852059 Terminated - ADHD Clinical Trials

Adherence to Stimulant Treatment in Attention-Deficit Hyperactivity Disorder (ADHD) Patients (ASTA)

ASTA
Start date: March 2009
Phase: Phase 4
Study type: Interventional

This study determined to measure non-adherence assessed by the number of non-adherent days during the clinical trial of 100 days using the Medication Event Monitoring System (MEMS). Study Design: - prospective - multi-centric - open-label - randomized - active-controlled trial