Adenovirus Clinical Trial
Official title:
Ad Sensor-based Real-time Diagnosis of Adenovirus
To develop a real-time diagnostic technique with Ad sensor for Adenovirus detection, the investigators conduct a prospective clinical study. In comparison with results from direct sequencing of Adenovirus, the investigators evaluate the performance of Ad sensor , including reproducibility, sensitivity, specificity, and cross-reaction. The potential factors which may interfere with the results would be investigated. With such technique, the investigators hope to make early diagnosis and give Adenovirus patients early treatment to reduce the complications and case-fatality rate.
1. Sample acquirement: At National Taiwan University Hospital in Taiwan, we will enroll
patients who have Adenovirus infection . We will take three throat swabs for each
patient: one for viral isolation, one for RT-PCR and the last for the Ad sensor - based
real-time diagnosis.
2. Ad sensor diagnosis: Ad sensor (structural chip-based optosensing virus probing
system), which is for the rapid and sensitive detection of viral antigen in medical
samples, will be used for analyzing the interaction kinetics between anti-Adenovirus
and its Adenovirus antigen present in patients'and normal samples.
3. Gold standard: viral isolation and RT-PCR
;
Intervention Model: Single Group Assignment, Masking: Double Blind (Investigator, Outcomes Assessor), Primary Purpose: Diagnostic
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