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Pilot Study of Haploidentical Donor Adenovirus Specific T-lymphocytes to Treat Refractory Adenovirus Infections — ADV-VSTS  

Adenovirus Infection Clinical Trial

Official title:
Open-Label Pilot Study of Haploidentical Donor Adenovirus Specific T Lymphocytes (ADV-VSTS) for the Treatment of Refractory Adenovirus Infection and/or Disease in Hospitalized Patients

Clinical Trial Summary

This open-label, single-arm, phase I/II clinical trial will assess the safety and efficacy of related donor adenovirus-specific T lymphocytes isolated from whole blood or leukapheresis products. The adenovirus-specific T lymphocytes will be generated automatically by the CliniMACS Prodigy using the CliniMACS Cytokine Capture System (IFN-γ) after incubation with MACS GMP PepTivator Peptide Pools of Hexon 5 for enrichment.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04722029
Study type Interventional
Source Nationwide Children's Hospital
Contact Melinda Triplet
Phone 6147226039
Email Melinda.Triplet@nationwidechildrens.org
Status Recruiting
Phase Phase 1/Phase 2
Start date October 1, 2021
Completion date October 1, 2024
View Details
See also
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