Adenoid Hypertrophy Clinical Trial
Official title:
Periostin Levels in Children With Adenoid Hypertrophy
Verified date | March 2020 |
Source | Bezmialem Vakif University |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational |
Periostin is a matricellular protein that has been shown to be a marker of Type 2 inflammation associated with airway eosinophilia. Matricellular proteins are highly expressed at sites of injury or inflammation. Periostin involves tissue fibrosis and remodeling in the nasal mucosa in some of the otolaryngologic diseases. The up-regulation of periostin expression has been shown in allergic rhinitis, chronic rhinosinusitis with nasal polyps , and aspirin intolerant asthma. In the light of these findings the investigators aimed to evaluate the relation between adenoid hypertrophy and periostin levels.
Status | Completed |
Enrollment | 40 |
Est. completion date | February 2, 2020 |
Est. primary completion date | January 10, 2020 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 2 Years to 12 Years |
Eligibility |
Inclusion Criteria: - The patients that were scheduled for adenoidectomy - Healthy subjects that had not any kind of allergy, adenoid hypertrophy symptoms Exclusion Criteria(for adenoid group): - The subjects that had any kind of corticosteroid treatment 1 month prior to surgery, and antihistaminic treatment 2 weeks prior to surgery Exclusion Criteria(for control group): - To have allergic rhinitis symptoms - To have high total IgE levels - To have positive skin prick test - To have acute respiratory tract infection - To have asthma To have any kind of endocrin disease |
Country | Name | City | State |
---|---|---|---|
Turkey | Bezmialem Vakif University | Istanbul | Fatih |
Lead Sponsor | Collaborator |
---|---|
Bezmialem Vakif University |
Turkey,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Serum Periostin level | Serum periostin levels of the adenoid group and control group will be compared. | 1 month | |
Primary | Adenoid tissue Periostin level | Periostin levels of the adenoid tissue and normal mucosal healthy tissue will be compared. | 1 month |
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