Clinical Trials Logo

Clinical Trial Summary

Periostin is a matricellular protein that has been shown to be a marker of Type 2 inflammation associated with airway eosinophilia. Matricellular proteins are highly expressed at sites of injury or inflammation. Periostin involves tissue fibrosis and remodeling in the nasal mucosa in some of the otolaryngologic diseases. The up-regulation of periostin expression has been shown in allergic rhinitis, chronic rhinosinusitis with nasal polyps , and aspirin intolerant asthma. In the light of these findings the investigators aimed to evaluate the relation between adenoid hypertrophy and periostin levels.


Clinical Trial Description

A total of 40 patients-age ranged between 2 and 12 years- were planned to enroll in the study prospectively. Patients that were scheduled to undergo adenoidectomy were included in the study group (adenoid group). The control group comprised of 20 healthy children who had previously been treated for anemia in the out-patient clinic of the Pediatrics Department and were clinically healthy with normal complete blood cell counts at their follow-up visits.

Serum samples were obtained from the two groups. The samples were centrifuged at 1500 g for 5 minute and stored in -80 oC for later analysis of periostin levels. Adenoid tissue and normal mucosal tissue samples were obtained from the adenoidectomy patients and stored in -80 oC for later homogenization and measurement of periostin levels. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT04152746
Study type Observational
Source Bezmialem Vakif University
Contact
Status Completed
Phase
Start date October 1, 2019
Completion date February 2, 2020

See also
  Status Clinical Trial Phase
Enrolling by invitation NCT02205580 - Continuous Intravenous Sufentanil Infusion for Postoperative Pain Management Following Tonsillectomy or Adeno-tonsillectomy in Children Phase 4
Not yet recruiting NCT05402267 - The Effects of Exosomes in Otitis Media With Effusion
Withdrawn NCT04302337 - Conventional Curettage Adenoidectomy vs Curettage Adenoidectomy With Transoral Endoscopic Residue Ablation in Children N/A
Completed NCT03677453 - Interactive Perioperative Teaching Platform (IPTP) N/A
Recruiting NCT04646525 - The Relationship Between Covid-19 Infection in Pediatric Patients and Secondary Lymphoid Organs
Not yet recruiting NCT03243565 - Effect of OM-85 on Respiratory Tract Infections and Adenoid Tissue in Children With Adenoid Hypertrophy Phase 4
Completed NCT03902314 - Lidocaine Infusion for Pain Relief in Children Scheduled for Tonsillectomy and Adenoidectomy Phase 4
Not yet recruiting NCT05291312 - EACA VS CCA in Postoperative Evaluation of Middle Ear Pressure N/A
Enrolling by invitation NCT06266429 - Metabolomic Profiling of Racial Disparity
Completed NCT04431128 - Adenoid Hypertrophy, Respiratory Complications and Correlation With Infant Feeding Position
Completed NCT03714919 - A Pilot Study: a Non-opioid Technique for Postoperative Adenoidectomy Pain Relief in Pediatric Patients Phase 2
Not yet recruiting NCT03890692 - Methods of Assessment of Adenoid Size N/A