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A Study of Markers of Glucocorticoid Effects in Patients With Addisons Disease (DOSCORT)

Addison Disease Clinical Trial

Official title:
A Dose-response Study of Markers of Glucocorticoid Effects (DOSCORT): A Double-blinded, Randomized, 2-dose, Cross-over Study

Clinical Trial Summary

DOSCORT is a 2-dose, cross-over study primarily aiming to identify and validate novel biological markers (biomarkers) of glucocorticoid effect in the human body. Patients with Addison´s disease, primary adrenal insufficiency, with life-long glucocorticoid replacement therapy will undergo 2 treatment periods where their usual hydrocortisone treatment will be replaced with betamethasone in physiological and supra physiological doses. Blood, saliva, urine, health related Quality-of-life self-assessment forms, measurements of physical activity and sleep quality will be collected from both treatment periods.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03210545
Study type Interventional
Source Göteborg University
Contact Johanna Mc Queen, MD
Phone 0046313428588
Email johanna.mcqueen@gu.se
Status Recruiting
Phase Phase 4
Start date March 2, 2021
Completion date December 31, 2021
View Details
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