Addiction Clinical Trial
Official title:
Effects of Noninvasive Brain Stimulation Methods (rTMS and tDCS) Treatment on Brain Function, Craving and Relapse Prevention
Addiction is known as a chronic relapsing brain disorder that has a high cost to patients, family and society. Its ranking in cause of death is 8th globally, and substance abuse contributes 5.4% of the total global burden of disease. Brain stimulation procedures such as repetitive trans-cranial magnetic stimulation (rTMS) and trans-cranial direct current stimulation (tDCS) are considered minimal risk interventions and are used for the treatment of depression, pain, and other neurological and psychiatric disorders. There is some evidence that rTMS applied to the left prefrontal cortex results in significantly lowered craving. To date, no studies have investigated the effects of a course of either rTMS or tDCS treatment on opioid craving, brain function, and relapse prevention in opioid addicts. Individuals with prescription opioid dependence experience high rates of desire and intense cravings to use opioids. The present study aims to examine the effects of a course of daily prefrontal rTMS and tDCS on brain function, desire and craving and help to relapse prevention in abstinence phase.
The investigators plan to compare and contrast TMS and tDCS alone or in combination to treat opioid abuse. We will use a 4 cell randomised parallel controlled trial, consisting of active or sham TMS, and active or sham tDCS [a-tDCS, a-TMS; s-tDCS, a-TMS; a-tDCS, s-TMS; s-tDCS, s-TMS). The investigators hypothesise that each of the active interventions alone will be superior to pure sham in reducing craving and use. Moreover, The investigators hypothesise that COMBINING the two active treatments will be synergistic and will produce the largest reductions in craving and use. ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Terminated |
NCT03576768 -
QuitFast: Evaluating Transcranial Magnetic Stimulation as a Tool to Reduce Smoking Directly Following a Quit Attempt
|
N/A | |
| Completed |
NCT04110626 -
Realistic Evaluation of Expériences Animées, a School-based Intervention in Nouvelle Aquitaine
|
||
| Completed |
NCT03007940 -
Using NIATx Strategies to Implement Integrated Services in Routine Care
|
N/A | |
| Not yet recruiting |
NCT04030858 -
The INFINITE Study: A Prospective Investigation of a Nutrient-dense Diet in Early Addiction Recovery
|
N/A | |
| Completed |
NCT03347643 -
The Effectiveness of tDCS on Internet Game Addiction
|
Phase 2 | |
| Active, not recruiting |
NCT02836080 -
Integrated Collaborative Care Teams for Youth With Mental Health and/or Addiction Challenges (YouthCan IMPACT)
|
N/A | |
| Completed |
NCT03221985 -
ESM Pilot: Mobile Phones and Psychology
|
N/A | |
| Completed |
NCT02556060 -
Lamotrigine for Ketamine Dependence Trial
|
Phase 2/Phase 3 | |
| Completed |
NCT02812810 -
Evaluation of the Efficacy of Repetitive Transcranial Magnetic Stimulation (rTMS) Low-frequency on Craving in Smoking Dependence
|
N/A | |
| Completed |
NCT01531153 -
Cognitive Enhancement as a Target for Cocaine Pharmacotherapy
|
N/A | |
| Recruiting |
NCT05976646 -
Phase Ib/2a Drug-drug Interaction Study of a Combination of 45mg Dextromethorphan With 105 mg Bupropion
|
Phase 1/Phase 2 | |
| Completed |
NCT04409106 -
The Turkish Version of the Parental Smartphone Use Management Scale (PSUMS)
|
||
| Not yet recruiting |
NCT06459609 -
Effect of Protein Supplementation on Craving in Subjects Hospitalised for Addiction Treatment
|
N/A | |
| Recruiting |
NCT05595759 -
Violence Against Women in Patients With Alcohol Substance Addiction Training
|
N/A | |
| Completed |
NCT04099173 -
A Brief Mindfulness-Based Intervention for Suicidal Ideation
|
N/A | |
| Recruiting |
NCT04959643 -
Systematic Screening for Viral Hepatitis B and C at the PASS Consultation of the Montpellier University Hospital
|
||
| Completed |
NCT04133688 -
Mobile App in Addiction
|
N/A | |
| Recruiting |
NCT04063267 -
Electronic Cigarettes as a Harm Reduction Strategy in Individuals With Substance Use Disorder
|
Phase 2 | |
| Completed |
NCT05114577 -
Recovery Sleepers: A Pilot Study of a Sleep Health Intervention for College Students in Recovery
|
N/A | |
| Terminated |
NCT02671240 -
Prognosis of Behavioral Addiction in Parkinson's Disease
|