Cardiovascular and Muscular Adaptations to Recreational Soccer and Strength Training in Elderly Healthy 65-75-year-old Men

Adaptation Reaction Clinical Trial

Official title:

Cardiovascular and Muscular Adaptations to Recreational Soccer and Strength Training in Elderly Healthy 65-75-year-old Men

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01530035
• Other study ID #: H-1-2011-013
• Status: Completed
• Phase: N/A
• First received: January 26, 2012
• Last updated: May 4, 2017
• Start date: March 2011
• Est. completion date: November 2012

Study information

• Verified date: May 2017
• Source: University of Copenhagen
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

A one-year intervention study of 41 healthy elderly men aged 65-75-years.Of these, 24 subjects are untrained men with no regular training activity for the last 5 years. After medical screening and pre-testing, they will be randomized into a football group (n=9), a strength-training group (n=9) or a sedentary control group (n=6). Additional 17 subjects are recruited from local football clubs and have been active football players for the last 40 years. Training will be performed 3x1 hour per week and evaluation will take place after 0, 3 and 12 months. Primary endpoints will be changes in cardiac and vascular structure and function measured by advanced echocardiography (tissue Doppler and speckle tracking imaging), and peripheral arterial tonometry (Endo--‐PAT device). Secondary endpoints will be evaluation of potential changes in VO2 max, blood pressure, muscle capillaries, lipid profile, circulating catecholamines, body composition, and insulin resistance.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 41
• Est. completion date: November 2012
• Est. primary completion date: October 2012
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Male
• Age group: 65 Years to 75 Years

Eligibility

Inclusion Criteria:

• 65-75 year old men

• healthy

• non-smoking

• non-hypertension

• non- cardiac disease

Exclusion Criteria:

• smoking

• cardiac disease

• biomechanical disorders

• cardiac medication

Related Conditions & MeSH terms

• Adaptation Reaction

Intervention

Other:
• physical training
training

Locations

Country	Name	City	State
Denmark	Institute of exercise and sports sciences, university of Copenhagen	Copenhagen

Sponsors (1)

Lead Sponsor	Collaborator
University of Copenhagen

Country where clinical trial is conducted

Denmark, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	cardiac adaptations	changes in cardiac function after 16 weeks and one year measured by advanced echocardiography (tissue Doppler and speckle tracking imaging)	after 16 weeks and one year
Secondary	Cardiorespiratory fitness, muscular adaptations, Bloodpressure and Glucose tolerance	Improvements in cardiorespiratory fitness assessed with VO2 max treadmill testing.; Changes in muscular tissue with biopsies from the vastus lateralis muscle. Changes in resting blood pressure in incline postion Changes in glucose tolerance with oral glucose tolerance testing	after 16 weeks and one year