Acute Type A Dissection Clinical Trial
Official title:
Mechanical Characterization of Ascending Aorta in Patients With Acute Type A Dissection and in Healthy Control Group Combined to Structural and Ultrastructural Analysis of Aortic Tissue
Acute type A aortic dissection is a frequent (3 cases per 100 000 people per year) and severe (spontaneous mortality 70%), needing an emergency surgical treatment. Surgical outcomes have improved with the development of surgical techniques, but the postoperative mortality remains high (15-30% at 30 days). Endovascular approach with the deployment of endoprosthesis sealing the proximal intimal tear is an attractive minimally invasive technique, which can represent an alternative to surgical repair especially in high risk patients.
Status | Recruiting |
Enrollment | 90 |
Est. completion date | August 2016 |
Est. primary completion date | January 2016 |
Accepts healthy volunteers | No |
Gender | Both |
Age group | 50 Years to 85 Years |
Eligibility |
Inclusion Criteria: - Patients aged 50 to 85 years - The information given search, - Aortic dissection evolving for less than 15 days confirmed Exclusion Criteria: - the acute aortic dissections against-indicated for aortic surgery (patient age, stroke or multiple organ failure) - Iatrogenic dissections, - Dissections related to congenital or hereditary disorder (abnormal connective tissue) or those occurring in subjects with a bicuspid aortic valve, - Intramural hematomas type A, - Patients under guardianship or trusteeship deprived of liberty. |
Time Perspective: Prospective
Country | Name | City | State |
---|---|---|---|
France | Assistance Publique Hôpitaux de Marseille | Marseille |
Lead Sponsor | Collaborator |
---|---|
Assistance Publique Hopitaux De Marseille |
France,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | measure the elastic properties of aortic wall | The distensibility, aortic strain will be measured as a function of changes of aortic diameter and pulse pressure. | one day | No |
Primary | Measurement of aortic diameters | The measurement will be done by transesophageal echocardiography simultaneously to the cuff brachial artery pressure. | one day | No |
Status | Clinical Trial | Phase | |
---|---|---|---|
Recruiting |
NCT03894033 -
Post-market Registry of the AMDS for the Treatment of Acute DeBakey Type I Dissection
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