Acute Spinal Cord Injury Clinical Trial
Official title:
Utilizing Contrast-enhanced Ultrasound (CEUS) to Assess Critically Hypo Perfused Spinal Cord Tissue After Injury
Patients with traumatic spinal cord injury (tSCI) often suffer from spinal cord swelling inside the thecal sac, which contains the spinal cord and surrounding fluid, leading to increased pressure on the spinal cord tissue and decreased spinal cord blood flow at the site of injury. The combination of increased pressure and decreased blood flow causes vascular hypo-perfusion of the spinal cord and exacerbates the severity of injury. This is also referred to as secondary injury. Thus, knowledge of spinal cord hypo-perfusion would allow the treating physician to optimize the hemodynamic condition of patient with acute spinal cord injury and potentially improve functional outcome. We plan to use contrast-enhanced ultrasound (CEUS) to determine decrease of blood flow in the spinal cord at the site of injury, during the routine surgery that these patients require to decompress and stabilize their injured spine. This may help us to determine the efficacy of certain treatments in improving blood flow and patients suffering from tSCI.
Status | Recruiting |
Enrollment | 30 |
Est. completion date | December 31, 2024 |
Est. primary completion date | December 31, 2024 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years and older |
Eligibility |
Inclusion Criteria: >18 Male or Female Acute <72 hours spinal cord injury American Spinal Injury Association (ASIA) grade A to D Medically stable to undergo routine decompression and spinal realignment Exclusion Criteria: <18 years of age Not clinically stable for spinal surgery Traumatic Brain Injury |
Country | Name | City | State |
---|---|---|---|
United States | Harborview Medical Center | Seattle | Washington |
Lead Sponsor | Collaborator |
---|---|
University of Washington |
United States,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Use of CEUS to improve post operative outcomes in acute spinal cord injury | Contrast-enhanced ultrasound (CEUS) to determine decrease of blood flow in the spinal cord at the site of injury | Intra-operative |
Status | Clinical Trial | Phase | |
---|---|---|---|
Recruiting |
NCT04811235 -
Optical Monitoring With Near-Infrared Spectroscopy for Spinal Cord Injury Trial
|
N/A | |
Completed |
NCT00406016 -
Acute Safety, Tolerability, Feasibility and Pharmacokinetics of Intrath. Administered ATI355 in Patients With Acute SCI
|
Phase 1 | |
Recruiting |
NCT05305118 -
TSCS for Acute SCI
|
N/A | |
Recruiting |
NCT05244408 -
"SCRIBBLE" Spinal Cord Injury Blood Biomarker Longitudinal Evaluation
|
||
Recruiting |
NCT05731986 -
Spinal Cord Transcutaneous Stimulation Effect on Blood Pressure in Acute Spinal Cord Injury (SCI)
|
N/A | |
Recruiting |
NCT06452264 -
Early Intervention for Information Processing Speed Deficits in Acute SCI: A Pilot Study
|
N/A | |
Recruiting |
NCT05426681 -
Spinal Cord Injury Neuroprotection With Glyburide
|
Phase 1 | |
Recruiting |
NCT05745298 -
The Use of Functional Electrical Stimulation in Conjunction With Respiratory Muscle Training to Improve Unaided Cough in Individuals With Acute Spinal Cord Injury
|
N/A | |
Terminated |
NCT01750684 -
AC105 in Patients With Acute Traumatic Spinal Cord Injury
|
Phase 2 | |
Recruiting |
NCT04475224 -
Phase 3 Study of KP-100IT in Subjects With Acute Spinal Cord Injury
|
Phase 3 | |
Enrolling by invitation |
NCT06030531 -
Spasticity and Functional Recovery After SCI
|
||
Active, not recruiting |
NCT03935724 -
Stem Cells in Spinal Cord Injury
|
Phase 2/Phase 3 | |
Recruiting |
NCT04054414 -
PMZ-1620 (Sovateltide) in Patients of Acute Spinal Cord Injury
|
Phase 2 | |
Recruiting |
NCT06000592 -
Safety, Feasibility, and Efficacy of TSCS on Stabilizing Blood Pressure for Acute Inpatients With SCI
|
N/A | |
Completed |
NCT02325414 -
Prevention of Bone Loss After Acute SCI by Zoledronic Acid
|
Phase 2 | |
Recruiting |
NCT02034669 -
Transplantation of Autologous Adipose Derived Stem Cells (ADSCs) in Spinal Cord Injury Treatment
|
Phase 1/Phase 2 | |
Terminated |
NCT02232165 -
Mean Arterial Blood Pressure Treatment for Acute Spinal Cord Injury
|
N/A | |
Completed |
NCT02260713 -
Autologous Bone Marrow Cell Transplantation in Persons With Acute Spinal Cord Injury- An Indian Pilot Study.
|
Phase 1/Phase 2 | |
Terminated |
NCT02524379 -
Spinal Cord Injury Neuroprotection With Glyburide
|
Phase 1/Phase 2 | |
Completed |
NCT01502631 -
Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of SUN13837 Injection in Adult Subjects With Acute Spinal Cord Injury (ASCI)
|
Phase 2 |