Acute Rhinosinusitis Clinical Trial
Official title:
Multicentre, Randomized, Double-blind, Parallel Group, Placebo-Controlled Study on the Therapeutic Efficacy and Safety of Beclomethasone Dipropionate Suspension for Inhalation 800 µg Twice Daily vs. Placebo Added to Antibiotic Therapy in Patients With Acute Rhinosinusitis
Intranasal corticosteroids are beneficial in the treatment of acute rhinosinusitis. As
adjunctive therapy to oral antibiotic treatment, mometasone furoate at doses of 200 μg or
400 μg twice daily, was well tolerated and significantly more effective in reducing the
symptoms of rhinosinusitis than antibiotic therapy alone. Furthermore,the addition of
fluticasone propionate to xylometazoline and antimicrobial therapy with cefuroxime improved
clinical success rates and accelerated recovery of patients with a history of chronic
rhinitis or recurrent sinusitis who present for treatment of acute rhinosinusitis.
The present study was planned to assess the effects of nebulised beclomethasone dipropionate
given as add-on therapy to standard care (oral antibiotics) in the treatment of acute
symptomatic rhinosinusitis. Antibiotic therapy will be at the physicians' discretion.
n/a
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT04131686 -
NAC Inhalation in the Treatment Of Symptomatic acuTe rhinosinUSitis
|
||
| Not yet recruiting |
NCT03517215 -
The Development and Testing of a Scaling Strategy for a Community-Based Primary Care Antimicrobial Stewardship Program
|
N/A | |
| Completed |
NCT05639959 -
Efficacy and Safety of New Mometasone Furoate Nasal Spray Formulation in Acute Rhinosinusitis Patients: A Randomized Clinical Trial
|
||
| Completed |
NCT00377403 -
Treatment of Acute Sinusitis
|
Phase 4 | |
| Completed |
NCT03693976 -
Non-interventional Study With Ectoin Containing and/or Decongesting Nasal Spray in Patients With Rhinosinusitis
|
||
| Completed |
NCT03480100 -
Non-interventional Study of Ectoin Nasal Douche (END01) in Patients With Acute Viral Rhinosinusitis
|
||
| Completed |
NCT02296814 -
Efficacy and Safety of Sinusitis Hevert SL Tablets Compared to Placebo in Adult Patients With Acute, Uncomplicated Rhinosinusitis
|
Phase 4 | |
| Completed |
NCT01553110 -
An Observational Study to Evaluate The Relationship of Nasal Mucus Properties and Symptoms
|
||
| Completed |
NCT01146860 -
Efficacy and Safety of a Herbal Medicinal Product (Dry Extract BNO 1016) in Patients With Acute Rhinosinusitis
|
Phase 3 | |
| Completed |
NCT00750750 -
Effectiveness and Safety of Once or Twice Daily Mometasone Nasal Spray Versus Amoxicillin Versus Placebo for Treatment of Acute Rhinosinusitis (Study P02683)
|
Phase 2 | |
| Completed |
NCT00751075 -
Effectiveness and Safety of Once or Twice Daily Mometasone Nasal Spray Versus Amoxicillin Versus Placebo for Treatment of Acute Rhinosinusitis (Phase 3 Study)(Study P02692)
|
Phase 3 |