Dialyzing Wisely - Improving the Delivery of Acute Renal Replacement Therapy to Albertans

Acute Renal Injury Clinical Trial

Official title:

Dialyzing Wisely - Improving the Delivery of Acute Renal Replacement Therapy to Albertans

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT05186636
• Other study ID #: Pro00112499
• Status: Recruiting
• Start date: January 12, 2023
• Est. completion date: June 30, 2025

Study information

• Verified date: October 2023
• Source: University of Alberta
• Contact: Dawn Opgenorth, RN
• Phone: 780 492-4698
• Email: dawno[@]ualberta.ca
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Implementation of an evidence-based and best practices acute RRT pathway aiming to decrease acute RRT program and healthcare systems costs while improving important patient-reported outcomes.

Description:

Providing acute dialysis to critically ill patients in ICU settings is resource and cost intensive. The daily costs of acute dialysis can range from $528/day for intermittent hemodialysis to $865/day for continuous renal replacement therapy. Providing acute dialysis in ICU settings requires a specialized team of nurses, educators, physicians and stakeholders to ensure its safe and effective prescription and delivery. Acute dialysis is typically delivered to some of the most acutely ill patients admitted to the ICU to support organ function and sustain life. At present, there is not a standardized approach to the prescription and delivery of acute dialysis therapy in ICUs across Alberta. The DIALYZING WISELY program will implement a standardized approach to the delivery of best practices for acute dialysis therapy to all patients who receive treatment across ICUs in Alberta.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 4500
• Est. completion date: June 30, 2025
• Est. primary completion date: December 31, 2024
• Accepts healthy volunteers: No
• Gender: All
• Age group: N/A and older

Eligibility

Inclusion Criteria:

Patient in one of 15 adult and 3 pediatric intensive care units in Alberta Receive acute RRT as part of their usual clinical care during the intervention period

Exclusion Criteria:

• none

Related Conditions & MeSH terms

• Acute Kidney Injury
• Acute Renal Injury

Intervention

Other:
• KPI reports
Quarterly
• Prescriber reports
Individualized prescriber reports for acute RRT initiation patterns along with targeted education to ensure that align with best evidence-based practices

Locations

Country	Name	City	State
Canada	Foothills Medical Centre	Calgary	Alberta
Canada	Peter Lougheed Centre	Calgary	Alberta
Canada	University of Alberta Hospital	Edmonton	Alberta
Canada	Red Deer Regional Hospital Centre	Red Deer	Alberta
Canada	Sturgeon Community Hospital	St. Albert	Alberta

Sponsors (2)

Lead Sponsor	Collaborator
University of Alberta	Alberta Innovates Health Solutions

Country where clinical trial is conducted

Canada, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Key performance indicators (KPI)	Changes in acute KPIs	Throughout intervention period up to 3 years
Primary	Health system costs	Acute RRT and healthcare systems costs	3 years
Secondary	Length of renal replacement therapy	Length of time patient receives RRT during their ICU stay	3 years
Secondary	ICU and hospital lengths of stay	Number of days patient spends in the ICU and hospital	3 years
Secondary	ICU and 90 day mortality	number of patients who die before ICU discharge or within 90 days of ICU stay	3 years
Secondary	Rates of RRT dependence at 90 days	number of patients who are receiving RRT at 90 days after ICU stay	3 years