Influence Continuous Veno-venous Hemodialysis the Autoregulation

Acute Renal Failure Clinical Trial

— dARICUCVVH  

Official title:

Influence of Continuous Veno-venous Hemodialysis on Cerebrovascular Autoregulation in Patients With Acute Renal Failure

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01376531
• Other study ID #: 837.041.10 2
• Status: Completed
• Phase: N/A
• First received: June 15, 2011
• Last updated: April 12, 2013
• Start date: January 2011
• Est. completion date: June 2011

Study information

• Verified date: April 2013
• Source: Johannes Gutenberg University Mainz
• Contact: n/a
• Is FDA regulated: No
• Health authority: Germany: Ethics Commission
• Study type: Observational

Clinical Trial Summary

The aim of the study is to characterize the influence of continuous veno-venous hemodialysis on the cerebrovascular autoregulation.

Description:

Patients at the intensive care unit who suffered acute renal failure with the need of continuous veno-venous hemodialysis will be investigated with continuous veno-venous hemodialysis and in a time window without continuous veno-venous hemodialysis to investigate the influence of continuous veno-venous hemodialysis on the cerebrovascular autoregulation.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 20
• Est. completion date: June 2011
• Est. primary completion date: June 2011
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• acute renal failure

• need for continuous veno-venous hemodialysis

• age >18 Years

Exclusion Criteria:

• Sepsis

• Preexisting cerebral illness

• traumatic brain injury

• Meningitis or encephalitis

• Pregnancy

Study Design

Time Perspective: Prospective

Related Conditions & MeSH terms

• Acute Kidney Injury
• Acute Renal Failure
• Renal Insufficiency

Intervention

Procedure:
• continuous veno-venous hemodialysis
continuous veno-venous hemodialysis

Locations

Country	Name	City	State
Germany	University medical centre	Mainz

Sponsors (1)

Lead Sponsor	Collaborator
Johannes Gutenberg University Mainz

Country where clinical trial is conducted

Germany, 

References & Publications (1)

Schramm P, Closhen D, Wojciechowski J, Berres M, Klein KU, Bodenstein M, Werner C, Engelhard K. Cerebrovascular autoregulation in critically ill patients during continuous hemodialysis. Can J Anaesth. 2013 Jun;60(6):564-9. doi: 10.1007/s12630-013-9912-z. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Change from Baseline cerebrovascular autoregulation to cerebrovascular autoregulation during continuous veno-venous hemodialysis	Is there an influence of continuous veno-venous hemodialysis at the cerebrovascular autoregulation, which would be a side effect with limiting use in patients with brain injury or the need of intensive monitoring of cerebral perfusion pressure in this patients.	1 Year	No