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Clinical Trial Summary

The study aims to investigate pathophysiological changes in coagulation in relation to inflammation in patients with acute pancreatitis. Serum and plasma is sampled repeated days from admission. Analysis will be done after recruitment. Specific biomarkers accuracy for prediction of moderate and severer acute pancreatitis will be calculated.

Clinical Trial Description

Inclusion criteria: Patients with acute pancreatitis admitted to Skåne University Hospital in Malmö Acute pancreatitis is defined as minimum 2 out of following: amylase levels >3 times upper reference limit, clinical signs of acute pancreatitis, imaging findings of acute pancreatitis) Exclusion criteria: <18 years of age >72 hours from onset of symptom until first sampling Patients with immunosuppression or autoimmune diseases are excluded from som parts of the study. Methods: Serum and plasma is sampled repeatedly during the hospital admission. Pre defined protocols are used for data collections of relevant clinical information. Specific aspects of inflammation, thrombin generation, platelet function and Microparticles will be analysed in serum or plasma during the first consecutive days of acute pancreatitis. Biomarkers for severe disease as well as correlation between inflammation and coagulopathy will be investigated. ;

Study Design

Related Conditions & MeSH terms

NCT number NCT05201053
Study type Observational [Patient Registry]
Source Region Skane
Status Completed
Start date May 1, 2017
Completion date June 1, 2023

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