Acute Pancreatitis Clinical Trial
Official title:
Coagulation Disturbances and Thrombosis in Acute Pancreatitis (Koagulopati Och Trombos Vid Akut Pankreatit-APK Studien)
The study aims to investigate pathophysiological changes in coagulation in relation to inflammation in patients with acute pancreatitis. Serum and plasma is sampled repeated days from admission. Analysis will be done after recruitment. Specific biomarkers accuracy for prediction of moderate and severer acute pancreatitis will be calculated.
Inclusion criteria: Patients with acute pancreatitis admitted to Skåne University Hospital in Malmö Acute pancreatitis is defined as minimum 2 out of following: amylase levels >3 times upper reference limit, clinical signs of acute pancreatitis, imaging findings of acute pancreatitis) Exclusion criteria: <18 years of age >72 hours from onset of symptom until first sampling Patients with immunosuppression or autoimmune diseases are excluded from som parts of the study. Methods: Serum and plasma is sampled repeatedly during the hospital admission. Pre defined protocols are used for data collections of relevant clinical information. Specific aspects of inflammation, thrombin generation, platelet function and Microparticles will be analysed in serum or plasma during the first consecutive days of acute pancreatitis. Biomarkers for severe disease as well as correlation between inflammation and coagulopathy will be investigated. ;
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