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Pancreatitis - Microbiome As Predictor of Severity — P-MAPS  

Acute Pancreatitis Clinical Trial

Official title:
Pancreatitis - Microbiome As Predictor of Severity

Clinical Trial Summary

This study is a multicentric prospective study initiated and coordinated from the University Medical Centre Goettingen. The study aims to evaluate the orointestinal microbiome as a potential biomarker for the course, severity and outcome of patients with acute pancreatitis.

Clinical Trial Description

This prospective translational study aims to evaluate the orointestinal microbiome as a potential biomarker for the course, severity and outcome of patients with acute pancreatitis. From each patient one buccal and rectal swab is collected within 72 h after hospital admission. Microbial composition will be determined by 16S and metagenomics Oxford Nanopore Sequencing (ONT) and correlated with the revised Atlanta classification as the primary endpoint. Secondary endpoints are the correlation of microbiome signatures with the length of hospital stay, numbers of interventions and mortality. To this end, alpha and beta diversity of microbiota are determined and compared between mild, moderately severe and severe acute pancreatitis. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04777812
Study type Interventional
Source University Medical Center Goettingen
Contact
Status Completed
Phase N/A
Start date February 17, 2020
Completion date February 23, 2024
View Details
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