Body Parameters as an Independent Predictor of Acute Pancreatitis

Acute Pancreatitis Clinical Trial

Official title:

Body Parameters as an Independent Predictor of Acute Pancreatitis: A Propensity Score-matched Case-control Study

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03482921
• Other study ID #: Ningbo4
• Status: Completed
• First received: March 23, 2018
• Last updated: March 23, 2018
• Start date: December 1, 2017
• Est. completion date: March 22, 2018

Study information

• Verified date: March 2018
• Source: Ningbo No. 1 Hospital
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational [Patient Registry]

Clinical Trial Summary

This study is to assess the predictive significance of visceral adipose tissue (VAT) and visceral adipose tissue /skeletal muscle tissue ratio (VAT/SMT ratio) for the prognosis in acute pancreatitis (AP) patients.

Description:

Acute pancreatitis (AP) is a sudden inflammation of the pancreas. However, one-fifth of patients may develop severe complications with a mortality between 10%-20% It remains a difficulty to find an effective method for prediction of severity of AP at early stage.

It is well-established that obesity (defined as body mass index[BMI]>30kg/m2 by the World Health Organization) is a risk factor for AP and increases the incidence of systemic complication, motality. There are a lot of parameters related to saropenic obesity, including areas of visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT), skeletal muscle tissue (SMT), and VAT/SMT ratio. it is unclear which parameter is the best predictor of severe AP. Thus, this study is aimed to investigate the association between these parameters and AP severity and find the best predictor of AP.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 1662
• Est. completion date: March 22, 2018
• Est. primary completion date: February 12, 2018
• Gender: All
• Age group: 18 Years to 100 Years

Eligibility

Inclusion Criteria:

1. diagnosed with AP

2. age >18 years

Exclusion Criteria:

1. age<18years

2. missing data in the electronic medical record

3. history of AP

Related Conditions & MeSH terms

• Acute Pancreatitis
• Pancreatitis

Locations

Country	Name	City	State
China	Ningbo NO.1 hospital	Ningbo	Zhejiang

Sponsors (1)

Lead Sponsor	Collaborator
Ningbo No. 1 Hospital

Country where clinical trial is conducted

China, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Comparisons of variables according to AP severity	Comparisons of variables according to AP severity by one-way analysis of variance (ANOVA) and Likelihood Ratio	the physical examination data in the year of 2017
Primary	Relationships between VAT and severity outcomes Relationships between VAT and severity outcomes Relationships between VAT and severity outcomes Relationships between body parameters and severity outcomes	Relationships between VAT and severity outcomes by Likelihood Ratio	the physical examination data in the year of 2017