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NCT03456557 Clinical Trial

The Use of Perfusion CT Derived Parameters as Early Acute Pancreatitis Severity Biomarker Compared to Clinico Biological Score

Acute Pancreatitis Clinical Trial

— K-PA  

Official title:
The Use of Perfusion CT Derived Parameters as Early Acute Pancreatitis Severity Biomarker Compared to Clinico Biological Score

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT03456557
Other study ID # K-PA Study
Secondary ID
Status Completed
Phase N/A
First received
Last updated
Start date March 7, 2018
Est. completion date December 9, 2018

Study information
Verified date April 2020
Source Poitiers University Hospital
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

The investigators to establish whether early microvascular permeability parameter evaluated by perfusion-CT could be good biomarkers for severity in acute pancreatitis.

Therefore the investigators want to compare 48 hours-clinico-biological systemic inflammatory response syndrome score to initial microvascular permeability parameters ( ktrans - capillary membrane permeability factor- and pancreatic blood flow ) calculated by OLEA software using inclusion perfusion CT.

Recruitment information / eligibility
Status Completed
Enrollment 15
Est. completion date December 9, 2018
Est. primary completion date December 9, 2018
Accepts healthy volunteers No
Gender All
Age group 18 Years to 100 Years
Eligibility Inclusion Criteria:

- Patient with acute pancreatitis (based on the Atlanta definition).

Exclusion Criteria:

- Patient under 18 yearras old

- Contraindication of injection of iodinated contrast medium

- Pregnancy

Study Design

Related Conditions & MeSH terms

Intervention

Radiation:
• Perfusion computed tomography.
Using specific post treatment imaging software ( Olea® ) we will calculatell permeability parameters : the pancreatic blood flow and the k-trans, capillary membrane permeability factor.

Locations
Country Name City State
France Chu de Poitiers Poitiers

Sponsors (1)
Lead Sponsor Collaborator
Poitiers University Hospital

Country where clinical trial is conducted

France, 

Outcome
Type Measure Description Time frame Safety issue
Primary Relation between CT perfusion calculated k-trans and clinicobiological SIRS score in early phase of acute pancreatitis. admission day
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