Acute Pancreatitis Clinical Trial
Official title:
Elevated Stearoyl-CoA Desaturase-1 Expression Predicts the Disease Severity and Clinical Outcomes of Severe Acute Pancreatitis
Verified date | November 2017 |
Source | Nanjing University School of Medicine |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational [Patient Registry] |
In this study, the investgatiors aimed to investigate the associations between serum levels of stearoyl-CoA desaturase-1(SCD-1) and the disease severity as well as the presence of adverse clinical events, such as local complications, organ failure, mortality and so on.In this prospective study, participants were divided into two groups based on serum SCD-1 concentration on admission and prospectively observe the disease severity and clinical outcomes of them.
Status | Not yet recruiting |
Enrollment | 216 |
Est. completion date | June 30, 2019 |
Est. primary completion date | December 30, 2018 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 18 Years to 75 Years |
Eligibility |
Inclusion Criteria: 1. Diagnosis of acute pancreatitis (Atlanta standard), abdominal pain occurred within one week of admission; 2. APACHEII score is more than 8 and Ranson score is greater than 3; 3. Age 18-75; 4. Obtaining informed consent. Exclusion Criteria: 1. Pregnancy pancreatitis; 2. Patients with the following disease history: severe cardiac, pulmonary, renal, liver function insufficiency or immunodeficiency disease. |
Country | Name | City | State |
---|---|---|---|
n/a |
Lead Sponsor | Collaborator |
---|---|
Nanjing University School of Medicine |
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | the incidence rate of infected pancreatic necrosis | 2-4 week after disease onset | ||
Secondary | the incidence rate of organ failure | the incidence rate of organ failure (transient or persistent) | 1-2 week after disease onset | |
Secondary | the incidence rate of local complications | acute peripancreatic fluid collections, pancreatic pseudocycts, acute necrotic collections and walled-off necrosis | 1-2 week after disease onset |
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