Study to Evaluate the Efficacy & Safety of HepaStem in Patients With Acute

Clinical Trial Summary

This is an interventional, double blind, randomized (2:1), and placebo-controlled study of 2 infusions of a 1 dose regimen of HepaStem in patients recently diagnosed (≤1 week) with ACLF grade 1 or 2 on top of Standard of Care (SoC), and for whom the diagnosis is not resolved on the day of infusion.

See also
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Terminated	`NCT02788240` - To Study the Influence of GCSF on Natural History of Acute On Chronic Liver Failure After the Acute Phase	N/A
Not yet recruiting	`NCT05772585` - Characterization of Metabolomic Fingerprints in Patients With Acute Liver Failure and Acute-on-chronic Liver Failure With Hepatic Encephalopathy
Withdrawn	`NCT05131230` - CytoSorb® in Patients With Acute on Chronic Liver Failure
Completed	`NCT02467348` - Incidence And Outcome Of Paracentesis Induced Circulatory Dysfunction In Acute-On-Chronic Liver Failure.	N/A
Not yet recruiting	`NCT06276907` - An Open-label Randomized Controlled Trial Comparing the Role of Therapeutic Plasma-exchange in Ameliorating Secondary Organ Dysfunctions in Patients With ACLF and Develop Biomarkers of Treatment Response	N/A
Recruiting	`NCT05146336` - CytOSorb TreatMent Of Critically Ill PatientS Registry
Completed	`NCT02307409` - Assessment of Coagulation Profile and Haematopoietic Responses in Patients With Acute-on-chronic Liver Failure During Systemic Inflammatory Response (SIRS) and Sepsis	N/A
Completed	`NCT03065699` - Safety and Performance Trial of DIALIVE Liver Dialysis Device in Acute On Chronic Liver Failure Patients	N/A
Recruiting	`NCT02757170` - Assessment of Coagulation Abnormalities in Acute on Chronic Liver Failure Patients Using Thromboelastography	Phase 4
Recruiting	`NCT04054037` - A Study of AARC Standards on Diagnosis and Treatment of Patients With HBV-ACLF in China (AARC China Study)

NCT number	NCT04229901
Study type	Interventional
Source	Cellaion SA
Contact
Status	Terminated
Phase	Phase 2
Start date	January 21, 2020
Completion date	May 10, 2024

Study to Evaluate the Efficacy and Safety of HepaStem in Patients With Acute on Chronic Liver Failure (ACLF) — DHELIVER

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms