Platelet Transfusion in HBV-related acute-on Chronic Liver Failure

Status Recruiting

Clinical Trial Summary

Acute-on-chronic liver failure (ACLF) is a syndrome that has recently been recognized as encompassing acute deterioration of liver function in patients with pre-existing chronic liver disease. It is associated with multi-organ failure and a high risk of short-term mortality. Thrombocytopenia is common in ACLF. In addition, the function of platelet is also compromised according to our previous data. The aim of this study is to explore whether platelet transfusion could reduce the short-term mortality rate of HBV-related ACLF. This is a single center, open labeled randomized controlled study. There are two arms. Subjects who is assigned to platelet transfusion group will receive both platelet transfusion (9 times/4 weeks, 1 unit each time) and standard medical treatment. While those in standard medical treatment group will receive standard medical treatment only. The major endpoint is 28-day transplant-free mortality rate.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03713489
Study type	Interventional
Source	Nanfang Hospital of Southern Medical University
Contact	Jinjun Chen
Phone	+8618588531001
Email	chjj@smu.edu.cn
Status	Recruiting
Phase	N/A
Start date	October 1, 2018
Completion date	September 30, 2019

View Details

See also
Status	Clinical Trial	Phase
Recruiting	`NCT05985863` - Human Umbilical Cord Mesenchymal Stem Cell Transplantation for The Treatment of Acute-on-Chronic Liver Failure	Phase 1/Phase 2
Not yet recruiting	`NCT04822922` - Safety of UC-MSC Transfusion for ACLF Patients	Phase 2
Recruiting	`NCT04578301` - Predicting Acute-on-Chronic Liver Failure After Surgical Intervention in Chronic Liver Disease
Completed	`NCT04983108` - Utility of Liver and Splenic Stiffness in Predicting Esophageal Varices in Patients With Acute on Chronic Liver Failure
Withdrawn	`NCT05940610` - The Safety and Efficacy of MSC-EVs in Acute/Acute-on-Chronic Liver Failure	Phase 1/Phase 2
Not yet recruiting	`NCT05036031` - Transplantation for EASL-CLIF and APASL ACLF Patients: a Retrospective Cohort Study
Recruiting	`NCT05019352` - Cytokine Adsorption in Acute-on-chronic Liver Failure	N/A
Recruiting	`NCT05421351` - Immune Profile, Neuronal Dysfunction, Metabolomics and Ammonia in Therapeutic Response of HE in ACLF
Completed	`NCT02321371` - Effect of Goal Directed Ammonia Lowering Therapy in Acute on Chronic Liver Failure Patients With Hepatic Encephalopathy.	N/A
Not yet recruiting	`NCT06069037` - SALT for Treatment of Patients With Early ACLF	N/A
Completed	`NCT02965560` - Exploring Biomarkers Predicting the Outcome of Acute-on-chronic Liver Failure
Withdrawn	`NCT03629015` - Safety Study of Stemchymal® in Acute Liver Failure	Phase 1
Recruiting	`NCT04621812` - Role of Fecal Microbiota in Predicting Graft Rejection and Sepsis Among Recipients of Living Donor Liver Transplant in First Year.
Recruiting	`NCT04157465` - Anti-fungal Strategies in Acute-on-Chronic Liver Failure Patients	N/A
Suspended	`NCT03737448` - TRimetazidine for acUte on Chronic Liver Failure STudy	Phase 1
Recruiting	`NCT06128421` - Individual Nutrition Support in HBV-ACLF Patients at Nutrition Risk	N/A
Recruiting	`NCT05700708` - Point-of-Care Echocardiography to Assess Impact of Dynamic Cardiac Function, Renal and Cardiac Biomarkers in Cirrhosis With Refractory Ascites
Completed	`NCT04238416` - Intravenous Branched Chain Amino Acids for Hepatic Encephalopathy in ACLF	Phase 1
Completed	`NCT03456518` - Pattern of Acute on Chronic Liver Failure in Patient With HCV Related Chronic Liver Disease
Recruiting	`NCT03987893` - PEG3350 in ACLF With Hepatic Encephalopathy	Phase 4