Acute Normovolemic Hemodilution Clinical Trial
Official title:
Acute Normovolemic Hemodilution Using Hydroxyethyl Starch (HES 130/0.4) in Patients Undergoing Off-pump Coronary Artery Bypass Grafting Surgery: Effects on Central and Peripheral Perfusion
To study the effects of Acute normovolemic hemodilution on central and peripheral perfusion in patients Undergoing off-pump coronary artery bypass grafting surgery
Off‑pump coronary artery bypass surgery is an alternative to conventional coronary artery
bypass grafting using cardiopulmonary bypass (CPB). It avoids adverse effects of CPB such as
systemic inflammatory response, impaired myocardial protection, and air or plaque embolism.
However, OPCAB surgery involves displacement and manipulation of the heart to expose target
coronary arteries. These manipulations cause hemodynamic instability as a result of transient
annulo‑mitral distortion and acute mitral regurgitation, compression of the right ventricle,
and impaired cardiac contractility due to epicardial stabilizers. signs of impaired perfusion
such as metabolic acidosis, increased serum lactate and decreased urine output are commonly
seen intraoperatively
Excessive surgical bleeding causes hypovolemia and hemodynamic instability, anemia, and
reduced oxygen delivery to tissues
Acute normovolemic hemodilution (ANH) is an alternative method of management of
intraoperative blood loss, in which a certain volume of blood is collected from the patient,
stored at room temperature and replaced by an equal volume of colloid solution. By the end of
surgery, this blood is returned to the patient, usually within eight hours of collection,
with little deterioration of platelets or coagulation factors
This work aims to study the effects of Acute normovolemic hemodilution on central and
peripheral perfusion in patients Undergoing off-pump coronary artery bypass grafting surgery
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| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT04369443 -
Application of Large Volume Acute Normovolemic Hemodilution in Cardiac Surgery
|
N/A | |
| Recruiting |
NCT06459141 -
The Effect of Hemodilution on Intraoperative Allogeneic Transfusion (HEAL)
|
N/A |