Acute Pancreatitis and Thrombosis (PATHRO) — PATHRO  

Acute Necrotizing Pancreatitis Clinical Trial

Official title: Management of Portoplenomesenteric Vein Thrombosis in Patients With Acute Pancreatitis : an Observational Study

Status Not yet recruiting

Clinical Trial Summary

Severe acute pancreatitis (AP) is a pathology with high morbidity and mortality. Portosplenomesenteric vein thrombosis is a well-known local complication of AP with a variable incidence, which can reach up to 50% in case of severe AP. However, there is no specific recommendation regarding the management of Portosplenomesenteric vein thrombosis. By analogy to all venous thrombosis, the European Society of Gastroenterology recommends curative anticoagulation. However, the efficacy of curative anticoagulation has never been evaluated by prospective studies. In addition, bleeding complications during AP occur in approximately 10% of patients and are associated with a poor prognosis.

The investigators wish to conduct an observational multi-center study with epidemiologic aims, including all patients admitted for AP and with a diagnosis of portosplenomesenteric vein thrombosis. The aim of this study is to evaluate the therapeutic management of these patients, the efficacy and safety of anticoagulant treatment for the treatment of Portosplenomesenteric vein thrombosis, and their outcomes.

Clinical Trial Description

The investigators will include prospectively all patients admitted for AP with a computed tomography diagnosis of portosplenomesenteric vein thrombosis. ;

Related Conditions & MeSH terms

• Acute Necrotizing Pancreatitis
• Pancreatitis
• Pancreatitis, Acute Necrotizing
• Portosplenomesenteric Venous Thrombosis
• Thrombosis
• Venous Thrombosis

• NCT number: NCT04642794
• Study type: Observational
• Source: Nantes University Hospital
• Contact: GARRET Charlotte, MD
• Phone: 0240084737
• Email: charlotte.garret@chu-nantes.fr
• Status: Not yet recruiting
• Start date: January 1, 2021
• Completion date: January 1, 2024