The Rapid Study: Randomized Phase II Study To Expedite Allogeneic Transplant With Immediate Haploidentical Plus Unrelated Cord Donor Search Versus Matched Unrelated Donor Search For AML And High-Risk MDS Patients

Acute Myeloid Leukemia (AML) Clinical Trial

Official title:

The Rapid Study: Randomized (RA) Phase (P) II Study To Expedite Allogeneic Transplant With Immediate (I) Haploidentical Plus Unrelated Cord Donor (D) Search Versus Matched Unrelated Donor Search For AML And High-Risk MDS Patients

Clinical Trial Details — Status: Terminated

Administrative data

• NCT number: NCT02648932
• Other study ID #: IRB15-0866
• Status: Terminated
• Phase: Phase 2
• Start date: February 4, 2016
• Est. completion date: April 2020

Study information

• Verified date: February 2021
• Source: University of Chicago
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The study seeks to compare time from formal search to hematopoietic cell transplantation (HCT) for patients 18 years and older, randomized between haplo-cord search and matched unrelated donor (MUD) search for patients with acute myeloid leukemia (AML) and high-risk myelodysplastic syndrome (MDS)

Description:

Primary Objectives

To compare time from formal search to hematopoietic cell transplantation (HCT) for patients 18 years and older, randomized between haplo-cord search and matched unrelated donor (MUD) search for patients with acute myeloid leukemia (AML) and high-risk myelodysplastic syndrome (MDS)

Secondary Objectives

• To compare the percentage of patients who undergo HCT in each study cohort

• To evaluate overall survival from time to randomization by study cohort

Recruitment information / eligibility

• Status: Terminated
• Enrollment: 9
• Est. completion date: April 2020
• Est. primary completion date: April 2020
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria for Search Phase:

1. Diagnosis of acute myeloid leukemia (AML) or high or very high-risk MDS by international prognostic scoring system revised for whom transplant is recommended

2. 18 years of age or older

3. Subject is likely to be considered for allogeneic transplant in the opinion of the transplant physician (based on age of patient, health, cytogenetics, and/or molecular characteristics).

4. Karnofsky Performance Status (KPS) >/= 70% at time of enrollment. An exception will be made for those with lower KPS at enrollment with an acute worsening that is likely to resolve in the treating physicians judgment (e.g., reversible infection,trauma, medication reaction, etc)

5. Ability to understand and the willingness to sign a written informed consent document for the Search Phase.

6. Patient willing to consider HCT

7. A preliminary search has identified:

1. An appropriate minimum 4/6 matched umbilical cord unit at intermediate resolution at HLA-A and B, and high resolution at HLA-DRB with a cell dose above 1 x 10(7) TNC/kg for a single umbilical cord blood (UCB) transplant AND

2. At least one potential 8/8 HLA-matched (HLA-A, -B, -C, and -DRB1) unrelated donor with a probability of 70% AND

3. Availability of a potential related haploidentical donor.

Exclusion Criteria for Search Phase:

1. Prior formal search was instituted

2. Diagnosis of acute promyelocytic leukemia (APL)

3. Known HLA matched related donor without contraindications to donate

4. Life expectancy severely limited by concomitant illness or uncontrolled infection

Inclusion Criteria for Transplant Phase

1. High-risk AML for which transplant is recommend based on cytogenetic, molecular and morphologic features. Patients must meet institutional standards for disease control prior to transplant.

2. For MDS. IPSS-revised criteria of high or very high at diagnosis.

3. Subject meets institutional criteria for transplant and has acceptable organ and marrow function as defined below:

1. Serum bilirubin < 2.0mg/dL unless Gilberts disease

2. Creatinine Clearance > 45 mL/min.1.73m2 as estimated by modified MDRD equation

3. Left ventricular function 40% or greater

4. DLCO corrected for hemoglobin >50%

5. KPS 70% or greater

4. An adequate graft for the defined donor type

1. Haplo-cord requires a haploidentical adult donor of 14 years of age and at least 50 kg, and a cord blood unit with at least 1.0 x 10(7) TNC/kg and a match of at least 4/6 by intermediate resolution for HLA-A and B and high resolution at DRB1. Donor provides standard of care consent for harvest following institutional policy. Any donor samples or donor research data would be obtained on separate donor research protocol.

2. For MUD requires a 7/8 or 8/8 HLA matched unrelated donor with high resolution matching at HLA-A, -B, -C, and DRB1. DP matching or DP permissive should be achieved when possible using T-cell epitope strategy.

5. Written informed consent for the transplant phase

Exclusion Criteria for Transplant Phase

1. Life expectancy severely limited by concomitant illness or uncontrolled infection

2. HIV-positive

Related Conditions & MeSH terms

• Acute Myeloid Leukemia (AML)
• Leukemia, Myeloid
• Leukemia, Myeloid, Acute
• Myelodysplastic Syndrome (MDS)
• Myelodysplastic Syndromes
• Preleukemia

Intervention

Biological:
• Haplo-Cord Transplant
For conditioning regimens, haplo-identical grafts will be selected by the Miltenyi Device

Procedure:
• Matched Unrelated Donor Transplant

Locations

Country	Name	City	State
United States	University of Chicago Cancer Center	Chicago	Illinois

Sponsors (1)

Lead Sponsor	Collaborator
University of Chicago

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Time to Transplant	Time to transplant will be measured from time of date of formal request to stem cell infusion date. Will also capture time from preliminary search to both formal search and transplant date.	Through one year after formal search
Secondary	Percentage of Patients Who Undergo Hematopoietic Cell Transplantation (HCT)	Compare percentage of patients who undergo HCT in each study cohort	Through one year after formal search
Secondary	Estimated Survival Time	Overall survival time was estimated from date of randomization and from date of transplant using Kaplan-Meier method.	From date of randomization up to 3 years