Acute Myeloid Leukemia, Adult Clinical Trial
Official title:
Effect of a Hyperproteic Hyperenergetic Enteral Formula on Body Composition, Muscle Strength and Concentration of Vascular Endothelial Growth Factor (VEGF) in Patients With Actue Myeloid Leukemia (AML) During the Hospital Stay
A randomized controlled clinical trial in two groups of supplementation with high protein enteral formula and a normocaloric enteral formula in two groups of 37 patients .
Patients with acute myeloid leukemia have a high risk of suffering sarcopenia, which
decreases the oncology therapy clinical response, functional ability and quality of life.
Chemotherapy is used in these patients, some of them inhibit angiogenesis and act in an
important way in physiological processes of muscle anabolism. The vascular endothelial growth
factor (VEGF) and its receptors (VEGFR) play a crucial role in both normal and malignant
angiogenesis. Activation of the VEGF pathway leads to endothelial cell activation,
proliferation and survival.
The objective of this study is to compare the effect of the use of a high protein, high
energy enteral with omega 3 formula (Supportan DKN) against a standard enteral formula
(Fresubin® Original DRINK) on body composition, days of hospital stay, quality of life,
associated muscular strength with levels of VEGF in patients with acute myeloid leukemia
during induction chemotherapy.
An open clinical trial was designed, in which a group of patients will receive, as part of
their nutritional requirements a hyperproteic hyperenergetic enteral formula versus standard
formula during the 21 days of the first cycle of antineoplastic treatment. We will measure
body composition, muscle strength and serum concentrations of VEGFR in both groups to be able
to compare its effect.
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