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Clinical Trial Summary

This is a single-center,single-arm,open-label phase I clinical study to determine the safety and efficacy of LILRB4 STAR-T cells in Monocytic Leukemia subjects.


Clinical Trial Description

This study will recruit LILRB4-positive monocytic leukemia subjects who will receive cyclophosphamide and fludarabine on days -5 to -3 prior to cell infusion, followed by LILRB4 STAR-T cells. The primary objective of the study was to evaluate the safety and tolerability of LILRB4 STAR-T cells in subjects with monocytic leukemia. The secondary objective was to evaluate the therapeutic efficacy, pharmacodynamics and pharmacokinetics of LILRB4 STAR-T cells. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05739409
Study type Interventional
Source Institute of Hematology & Blood Diseases Hospital
Contact Jianxiang Wang, PhD
Phone +86-022-23909120
Email wangjx@ihcams.ac.cn
Status Not yet recruiting
Phase N/A
Start date February 2023
Completion date August 2024

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