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Efficacy of Prophylactic Treatment of Oral Prochlorperazine for Acute Mountain Sickness — PAMS  

Acute Mountain Sickness Clinical Trial

Official title:
A Prospective Single-Blinded Randomized Field-Based Trial to Evaluate the Prophylactic Treatment of Oral Prochlorperazine for Acute Mountain Sickness

Clinical Trial Summary

A field-based trial was conducted to determine if oral prochlorperazine demonstrates efficacy in the prophylactic treatment of AMS, and/or decreases the incidence of the symptoms of acute mountain sickness including headache, GI symptoms, fatigue and dizziness based on data collected in the Lake Louise AMS score.

Clinical Trial Description

This was a prospective, single-blinded, field-based interventional trial involving consenting, healthy subjects aged >17 years. The study was conducted on the big Island of Hawaii, at sea level and at the summit of Mauna Kea volcano. Following randomization, subjects received either placebo or 10mg prochlorperazine, then immediately drove for 2 hours from sea level to the volcano summit (4205m). Participants spent 240 min at the summit, and they recorded their symptoms. AMS was defined by the previously validated Lake Louise Acute Mountain Sickness Score (LLAMS). Categorical variables were analyzed by chi-square; continuous variables analyzed by t-tests. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06310642
Study type Interventional
Source CHRISTUS Health
Contact
Status Completed
Phase Phase 4
Start date May 20, 2021
Completion date March 13, 2023
View Details
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