The Feasibility of a Radiological Score Based on CT Signs for Recognizing Salvageable Bowel in Acute Mesenteric Ischemia

Acute Mesenteric Ischemia Clinical Trial

— AMESIradiol  

Official title:

The Feasibility of a Radiological Score Based on Quantified Analysis of Computed Tomography Signs for Recognizing Salvageable Bowel in Acute Mesenteric Ischemia: A Retrospective Analysis of Prospective Study

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT06445660
• Other study ID #: 03.01.2024
• Status: Recruiting
• Start date: June 6, 2022
• Est. completion date: December 31, 2024

Study information

• Verified date: May 2024
• Source: University of Tartu
• Contact: Joel Starkopf
• Phone: 53318400
• Email: joel.starkopf[@]ut.ee
• Is FDA regulated: No
• Study type: Observational [Patient Registry]

Clinical Trial Summary

Computed tomography (CT) is the standard modality for scanning patients with critical acute abdominal conditions, including suspected acute mesenteric ischemia (AMI). CT imaging can potentially differentiate between reversible and irreversible ischaemic damage of the bowel. This moment is pivotal in selecting the treatment strategy for AMI - in the absence of irreversible damage; reperfusion therapy can preserve intestinal viability, thereby avoiding the need for bowel resection. The present study tests the hypothesis that combining several symptoms may enhance the diagnostic performance of CT scanning in detecting salvageable bowel in patients with AMI. This study is an ancillary component of the AMESI study (Clinical Trials: NCT05218863) - a prospective, multicentre observational study aimed at identifying the incidence and describing the outcomes of acute mesenteric ischemia (AMI) in adult hospitalized patients. The ultimate purpose of the present study is to create a computed tomography-based radiological score for the assessment of bowel viability in patients with AMI.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 200
• Est. completion date: December 31, 2024
• Est. primary completion date: April 5, 2023
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Participant in AMESI study
• confirmed or suspected acute mesenteric ischaemia
• CT scan of the entire abdominal cavity / full body using intravenous contrast media is available

Exclusion Criteria:

• Scans without the use of an intravenous contrast media or those covering only a partial area of the abdomen will be excluded.

Related Conditions & MeSH terms

• Acute Mesenteric Ischemia
• Ischemia
• Mesenteric Ischemia

Locations

Country	Name	City	State
Estonia	Tartu University Hospital	Tartu

Sponsors (1)

Lead Sponsor	Collaborator
University of Tartu

Country where clinical trial is conducted

Estonia, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Frequency rate	Frequency rate of common radiological signs in AMI patients with and without salvageable bowel.	up to one month
Secondary	Frequency rate	Frequency rate of common radiological signs/findings among patients with confirmed and suspected but eventually not confirmed AMI.	up to one month
Secondary	Performance of the radiological score	Performance of the radiological score in patients with different types of AMI.	up to one month