Acute Lymphoblastic Leukemia Clinical Trial
Official title:
Pharmacogenetic Study of Antimitotic Therapies Involved in Hepatic Veno-occlusive Disease in Children With Nephroblastoma or Acute Lymphoblastic Leukemia
Hepatic veno-occlusive diseases (VOD) during cancer treatment in children are serious
toxicities that have occurred with interruptions of chemotherapy and risk of relapse. In
addition, these toxicities have a negative impact on the patient's quality of life, serious
long-term sequelae and are potentially fatal in children.
The risk factors associated with the occurrence of these complications are, to date, unknown,
at the exception to the exposition to certain treatments (6-thioguanine, busulfan,
actinomycin D, radiotherapy, etc.). To understand the effects of this toxicity and those of
susceptibility to the disease becomes a major issue in the treatment of these children.
Case-control study, nested in two French multicenter cohorts, on pharmacognenetic, biological
and clinical susceptibility factors associated with the occurrence of hepatic veno-occlusive
disease during the anticancer treatment for nephroblastoma or acute lymphoblastic leukemia,
with centralized genetic analysis.
After obtaining consent (patient or parents for minor patients), a blood sample is collected
during the routine follow-up consultation and tubes are sent directly to Paris for the
pharmacogenetic analysis at the end of the study.
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