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Clinical Trial Summary

This is a single arm, open-label, phase 1/2 study to evaluate the safety and efficacy of anti-CD19 CAR-T cells in patients with relapsed or refractory B cell Malignancies.


Clinical Trial Description

Chimeric antigen receptor (CAR)-modified T cells (CAR-T cells) have the capabilities to recognize tumor associated antigen and kill tumor cells specifically. CAR-T therapy showed great effect on patients with relapsed or refractory B cell malignancies. CAR consists of single chain variable fragment (scFv) and activation domain of T cell. In preclinical study, the researchers constructed a second generation CAR containing CD137 costimulatory domain. This study aims to evaluate the safety and effectiveness of anti-CD19 CAR-T cells in patients with relapsed or refractory B cell Malignancies. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT02965092
Study type Interventional
Source Wuhan Sian Medical Technology Co., Ltd
Contact Yu Hu, M.D., Ph.D
Phone 86-13986183871
Email dr_huyu@126.com
Status Recruiting
Phase Phase 1/Phase 2
Start date December 2, 2015
Completion date December 2021

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