Acute Lymphoblastic Leukemia Clinical Trial
Official title:
Phase III Study to Compare Haplo-identical HSCT Versus Chemotherapy in First Remission for Standard-risk Adult Acute Lymphoblastic Leukemia
The survival of adult patients with standard-risk acute lymphoblastic leukemia(ALL) need to improve. We want to compare the efficacy of haplo-identical hematopoietic stem cell transplantation (HSCT) with chemotherapy for adult(age:18-39 years old) ALL patients in first phase of complete remission (CR1)
Although the high complete remission rate (80%-90%) can be achieved, the long-term survival
rate of standard-risk adult patients with acute lymphoblastic leukemia(ALL) is only 25%-55%
when they receive chemotherapy alone. The survival rate can be further improved uo to 50%-75%
when they receive HLA-matched HSCT However, the chance of finding a HLA-matched donor is low,
especially in China. Alternative donor such as halpo-identical related donor might be an
choice.
Our retrospective analysis showed about 59% overall survival could be achieved when
standard-risk adult ALL patients received halpo-identical HSCT.Therefore, we start this
randomization controlled trial to compare the efficacy of haplo-identical HSCT with
chemotherapy for adult(age:18-39 years old) ALL patients in CR1.
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