Acute Lymphoblastic Leukemia Clinical Trial
Official title:
Motor Proficiency And Physical Activity in Adult Survivors of Childhood ALL
The primary goal of this study is to provide comprehensive and objective information on impairments of musculoskeletal health, sensory function, and fitness among a large group of childhood ALL survivors, and to define high risk groups by assessing treatment factors that contribute to impaired function. This study includes a direct, objective evaluation of musculoskeletal function, sensory capacity, fitness, and physical activity patterns among adults who were treated for childhood ALL at St. Jude Children's Research Hospital (SJCRH) between 1980 and 1999. Among 899 ALL survivors, all of whom are eligible for an institutionally funded clinical study of medical late effects, the study will recruit 364 to participate in our evaluations. The study will also recruit 364 individuals for a comparison group, frequency matching on race/ethnicity, age and gender.
Status | Completed |
Enrollment | 807 |
Est. completion date | April 2013 |
Est. primary completion date | April 2013 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Both |
Age group | 18 Years and older |
Eligibility |
Inclusion Criteria:(ALL survivors): 1. Research participant who is a survivor of childhood ALL who was treated at St. Jude Children's Research Hospital between 1980 and 1999 2. Research participant must be at least ten years from diagnosis 3. Research participant must be at least 18 years of age at the time of the scheduled evaluation Exclusion Criteria (ALL survivors): 1. Research participant who has Down Syndrome or congenital cognitive, musculoskeletal or cardiopulmonary impairments that interfere with motor function 2. Research participant currently pregnant or lactating 3. Research participant age 17 years or less 4. Research participant undergoing active treatment for cancer Inclusion Criteria (Comparison Group) 1. Research participant is a sibling, parent, relative or friend of a current or former St. Jude patient. 2. Research participant must be at least 18 years of age at the time of the scheduled evaluation Exclusion Criteria (Comparison Group) 1. Research participant who has Down Syndrome or congenital cognitive, musculoskeletal or cardiopulmonary impairments that interfere with motor function 2. Research participant currently pregnant or lactating 3. Research participant age 17 years or less 4. Research participant has a medical history of cancer 5. Research participant is a first degree relative of a survivor participating in MTRPAL |
Observational Model: Case Control, Time Perspective: Cross-Sectional
Country | Name | City | State |
---|---|---|---|
United States | St. Jude Children's Research Hospital | Memphis | Tennessee |
Lead Sponsor | Collaborator |
---|---|
St. Jude Children's Research Hospital | National Cancer Institute (NCI), University of Pittsburgh, University of Tennessee |
United States,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Ascertain the prevalence of musculoskeletal, sensory, and fitness impairments among adult survivors of childhood ALL. | Day 1-2 | No | |
Secondary | Compare physical activity patterns between adult survivors of childhood ALL and a frequency matched control group. | Day 1-7 | No | |
Secondary | Describe the association between habitual physical activity and energy expenditure among ALL survivors. | Day 1-7 | No | |
Secondary | Explore the associations between musculoskeletal and sensory health, and physical activity patterns among adult survivors of childhood ALL. | Day 1-7 | No |
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