Acute Lymphoblastic Leukemia Clinical Trial
Official title:
GIMEMA LAL 0496: High-dose Anthracycline in the Induction Regimen for the Treatment of Adult Acute Lymphoblastic Leukemia. A Prospective Multicentric GIMEMA Trial.
The present study aims at verifying the state of the art in what this illness concerns and at organizing a centralized samples analysis.
The present trial is a prospective multicentric GIMEMA study, in which adult ALL patients are
extensively analyzed at diagnosis by a multiparametric approach including CC and molecular
analysis for the following gene rearrangements: BCR-ABL, MLL-AF4, E2A-PBX1, TEL-AML1, MLL,
p15 and p16 deletion in order to give place to a carefully characterization of the genetic
lesions occurring in adult ALL and to evaluate their prognostic significance in a large
cohort of patients homogeneously treated.
This study requires a central handling and analysis of bone marrow (BM) or peripheral blood
samples at presentation.
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