Lymphoblastic Lymphoma Clinical Trial
Official title:
Part I: Incidence, Clinical Course and Significance of MRI for Early Diagnosis of Osteonecrosis in Children and Adolescents With Acute Lymphoblastic Leukemia (ALL) or Lymphoblastic Lymphoma (LBL) Part II: Susceptibility for Aseptic Osteonecroses in Children and Adolescents With Chemotherapy for ALL or LBL
Nowadays approximately 80% of children and adolescents with acute lymphoblastic leukaemia
(ALL) or lymphoblastic lymphoma (LBL) can be cured and become long-term survivors. Avascular
osteonecroses (ON) appear as serious side-effect of antileukaemic treatment. Frequently ON
are first diagnosed at higher and than irreversible stages (ARCO III, IV). At these advanced
stages curative treatment options are not available. Hence ON are associated with
considerable morbidity concerning pain and immobility and go along with long-term impairment
of quality of life. Therefore early diagnosis of ON in the follow-up of children and young
adults with ALL or LBL is a pressing object.
Within the prospective multicentric observational OPAL-trial patients at risk (aged 10 years
or older) treated according to the clinical trials ALL-BFM(Berlin-Frankfurt-Muenster Study
Group), COALL or NHL (Non Hodgkin Lymphoma)-BFM in Germany should be examined with regard to
the development of ON. By using a treatment associated, risk orientated assessment and
examination incidence, symptoms and the clinical course of ON are investigated. The validity
of MRI screening in the early diagnosis of ON in children and young adults is analysed.
Systematical investigation of patients under antileukaemic treatment is intended to
contribute to risk adapted diagnostic strategies and to serve as data base for the
subsequent evaluation of preventive and interventional approaches for the treatment of ON.
Long-term objective is the reduction of ON-associated morbidity.
n/a
Observational Model: Cohort, Time Perspective: Prospective
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