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Acute Lymphatic Leukemia clinical trials

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NCT ID: NCT05250869 Completed - Lymphoma Clinical Trials

Comparative Quantification of MTX and Its Metabolites Post Glucarpidase

Start date: July 6, 2022
Phase:
Study type: Observational

Acidification (i.e., addition of hydrochloric acid) of plasma samples from patients who have received Glucarpidase post high-dose MTX treatment is regarded as a necessary preanalytic step to avoid further in vitro enzymatic cleavage of MTX. However, it is unclear whether this acidification step is essential. A comparative study, which evaluates concentrations of MTX and its metabolites in paired (acidified versus non-acidified) plasma samples, has not yet been performed. Processing plasma samples without acidification would facilitate quantification of MTX, including plasma samples from patients treated at centers without adequate laboratory facilities.