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Clinical Trial Summary

The study is aimed at assessing changes in the brain of patients from 6 to 18 years old with a diagnosis of acute lymphoblastic leukemia during chemotherapy.


Clinical Trial Description

Children with acute lymphoblastic leukemia receive long-term combined chemotherapy treatment, one of the main part of this treatment is methotrexate. Methotrexate can cause acute, subacute, and long-term neurotoxicity. Clinical symptoms of neurotoxicity, such as seizures, aphasia, are often associated with leukoencephalopathy. However, leukoencephalopathy may develop asymptomatically in children receiving methotrexate. The effect of chemotherapy on the neurological status of patients is widely covered in the literature. There are very few studies devoted to the quantitative assessment of MRI parameters, especially in children. MRI is a non-invasive method that does not harm the patient and can be used to assess absolutely all structures of the brain. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT04767152
Study type Interventional
Source Federal Research Institute of Pediatric Hematology, Oncology and Immunology
Contact Nataliia f Kriventsova
Phone +7 (495)2876570
Email nataliya.krivencova@fccho-moscow.ru
Status Recruiting
Phase N/A
Start date February 16, 2021
Completion date January 21, 2026

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