Association Between Telomere Length and Cardiac Dysfunction

Acute Leukemia Clinical Trial

Official title:

Association Between Relative Telomere Length and Severity of Cardiac Dysfunction

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04409379
• Other study ID #: YL2019100602
• Status: Completed
• Start date: January 1, 2019
• Est. completion date: May 1, 2020

Study information

• Verified date: May 2020
• Source: Fourth Military Medical University
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Compelling epidemiological evidence indicates that alterations of relative telomere length (RTL) are associated with cardiac dysfunction caused by chemotherapy in children with acute leukemia (AL).The aim of this study was to explore association between RTL content in peripheral blood cells could be used as a risk predictor for severity of cardiac damage.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 300
• Est. completion date: May 1, 2020
• Est. primary completion date: May 1, 2020
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 1 Year to 16 Years

Eligibility

Inclusion Criteria:

• 1. histological confirmed acute leukemia; 2. Preparing for chemotherapy;

Exclusion Criteria:

• 1.history of other malignancy; 2.blood transfusion within one month or prior bone marrow transplantation; 3.patients who reluctant to sign informed consent.

Related Conditions & MeSH terms

• Acute Leukemia
• Cardiac Toxicity
• Cardiotoxicity
• Childhood Cancer

Intervention

Diagnostic Test:
• Relative telomere length
Relative telomere length in peripheral blood cell

Locations

Country	Name	City	State
China	Xiao-Fan Zhu	Tianjin	Tianjin

Sponsors (1)

Lead Sponsor	Collaborator
Fourth Military Medical University

Country where clinical trial is conducted

China, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Relative telomere length	The ratio of RTL to hemoglobin contents was calculated for each sample from standard curves. After that, the ratio for each sample was normalized to a calibrator DNA in order to standardize between different runs, and then defined as the measurement of relative mtDNA contents.Relative expression of mtDNA were measured in young adults suffered from AL.	From date of admission until the date of discharging from hospital, assessed up to 5 days