CD19-CART Treatment for ALL

Status Completed

Clinical Trial Summary

This study aims to evaluate the safety and efficacy of a novel CD19-CART in the treatment of refractory or recurrent ALL.

Clinical Trial Description

Chimeric antigen receptor T cell (CART) is a kind of engineered immunotherapy by transferring an artificial antigen binding receptor and also intercellular co-stimulating molecules into T cells. This kind of engineered T cells gains the ability to recognize antigen specific tumor cells and initiate the killing process in a HLA-independent way. CD19 is the specific cellular marker of B lineage acute leukemia (B-ALL), thus CD19-CART will be efficient in treating B lineage ALL. The investigators have constructed two kinds of CD19-CART. One is equipped with a murine CD19 scFv (single-chain variable fragmentt), while the other with a humanized scFv. This study aims to evaluate the safety and efficacy of both murine and humanized CD19-CART in treating refractory or recurrent ALL. ;

Study Design

Related Conditions & MeSH terms

Acute Leukemia

Clinical Trial Details

NCT number	NCT03232619
Study type	Interventional
Source	Shanghai Bioray Laboratory Inc.
Contact
Status	Completed
Phase	Phase 1/Phase 2
Start date	August 1, 2018
Completion date	September 15, 2020

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