Phase I Study of Lenalidomide in Patients With Acute Leukemia

Status Terminated

Clinical Trial Summary

Lenalidomide is a drug that alters the immune system and it may also be directly toxic to tumor. Therefore, in theory, it may reduce or prevent the growth of cancer cells or directly kill them. We will be studying how lenalidomide can be used to decrease bone marrow blast cells in preparation for a bone transplant.

Clinical Trial Description

We hypothesize that lenalidomide in high doses can be used to decrease bone marrow blast count in patients with relapsed or refractory acute myeloid leukemia in preparation for an allogeneic stem cell transplant with acceptable toxicities that are no worse than current cytotoxic chemotherapeutic agents. The known dose-limiting toxicity at 75 mg was excessive fatigue in a previous phase I trial which in this study may be irrelevant as all study participants will have an in-patient status. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT01615042
Study type	Interventional
Source	University of California, Davis
Contact
Status	Terminated
Phase	Phase 1
Start date	August 2012
Completion date	May 2017

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