Acute Kidney Failure Clinical Trial
Official title:
Neutrophile Gelatinase Associated Lipocalin Evaluation in Septic Acute Kidney Injury
Acute kidney injury (AKI) is a major organ failure in septic shock. Current medical tests
(serum creatinine and urea) cannot identify AKI until approximately 48 hours after it
occurs. Neutrophil gelatinase-associated lipocalin (NGAL) may be able to predict ischemic
AKI more effectively and faster than serum creatinine and urea levels.
The purpose of this study is to take a blood sample from patients at admission and then at
24 and 48 hours after to test their plasma for NGAL and compare the NGAL levels to their
creatinine and urea levels. The investigators hypothesize that NGAL is an earlier marker to
classify the kidney failure as acute tubular necrosis or pre-renal azotemia than creatinine
and urea.
Primary Outcome Measures:
To correlate elevated serum NGAL with the diagnosis of intrinsic acute kidney injury in
septic shock
Secondary Outcome Measures :
To compare serum NGAL with serum creatinine, serum urea and urine output in septic AKI Death
within the intensive care unit Death from all causes at 28 days after inclusion
;
Observational Model: Cohort, Time Perspective: Prospective
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