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Dose-finding Study Using Pentostatin for Injection in the Treatment of Steroid-refractory aGvHD

Acute Graft Versus Host Disease Clinical Trial

Official title:
A Sequentially Adaptive, Open Label, Dose-finding, Phase I/II Trial of Pentostatin in the Treatment of Steroid-refractory Acute Graft Versus Host Disease (aGvHD)

Clinical Trial Summary

To determine a safe and effective dose of pentostatin in steroid-refractory aGvHD and to identify the minimal effective dose of pentostatin defined as the lowest dose that produces a response in 20% or more of patients while producing treatment failure (defines as death, grade 3/4 toxicity, or progressive disease) in 40% or less of patients.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT00032773
Study type Interventional
Source Astex Pharmaceuticals, Inc.
Contact
Status Terminated
Phase Phase 1/Phase 2
Start date January 30, 2002
Completion date November 3, 2005
View Details
See also
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