Clinical Trials Logo
  1. Home
  2. Acute Graft Versus Host Disease
  3. NCT00032773

Dose-finding Study Using Pentostatin for Injection in the Treatment of Steroid-refractory aGvHD

Acute Graft Versus Host Disease Clinical Trial

Official title:
A Sequentially Adaptive, Open Label, Dose-finding, Phase I/II Trial of Pentostatin in the Treatment of Steroid-refractory Acute Graft Versus Host Disease (aGvHD)

Clinical Trial Summary

To determine a safe and effective dose of pentostatin in steroid-refractory aGvHD and to identify the minimal effective dose of pentostatin defined as the lowest dose that produces a response in 20% or more of patients while producing treatment failure (defines as death, grade 3/4 toxicity, or progressive disease) in 40% or less of patients.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT00032773
Study type Interventional
Source Astex Pharmaceuticals, Inc.
Contact
Status Terminated
Phase Phase 1/Phase 2
Start date January 30, 2002
Completion date November 3, 2005
View Details
See also
  Status Clinical Trial Phase
Terminated NCT01140984 - Intra Arterial (IA) Steroids Infusion for Hepatic Acute Hepatic Graft Versus Host Disease (aGVHD) N/A
Completed NCT00803010 - Graft-Versus-Host Disease (GVHD) Prophylaxis After Allogeneic Peripheral Blood Hematopoietic Cell Transplantation Phase 2
Withdrawn NCT04280471 - Fecal Microbiota Transplantation for the Treatment of Severe Acute Gut Graft-Versus-Host Disease Phase 1
Withdrawn NCT02425813 - Methylprednisolone Sodium Succinate in Treating Patients With Acute Graft-versus-Host Disease of the Gastrointestinal Tract Phase 2
Terminated NCT00038792 - Phase I/II Trial rHuKFG for the Treatment of Steroid Refractory Gastrointestinal Acute GVHD Phase 1/Phase 2
Terminated NCT04521777 - Studying Changes in Physical Function Measures in Stem Cell Transplant Patients at Risk for Steroid Myopathy N/A
Terminated NCT02436460 - A Study of AbGn-168H in Patients With Steroid Refractory Acute Graft-vs-Host Disease After Donor Stem Cell Transplant Phase 1
Not yet recruiting NCT01596192 - PETCT for Diagnosing and Monitoring Acute GVHD N/A
Completed NCT00726375 - The Use of Etanercept Enbrel as Sole Treatment for Grade I Acute Graft Versus Host Disease Phase 3
Recruiting NCT05823675 - Safety and Clinical Activity of Itolizumab in aGVHD Phase 1
Not yet recruiting NCT06386445 - Study on the Serum Metabolic Markers and Early Complications After Allo-HSCT： Cohort Study
Recruiting NCT05443425 - Leflunomide in Combination With Steroids for the Treatment of Acute Graft-versus-Host Disease After Donor Stem Cell Transplant for Hematologic Malignancies Phase 1
Recruiting NCT03158896 - Evaluation of Umbilical Cord-Derived Wharton's Jelly Stem Cells for the Treatment of Acute Graft Versus Host Disease Phase 1
Not yet recruiting NCT06444022 - hAESCs Prevent Acute Graft-versus-host Disease After Hematopoietic Stem Cell Transplantation Early Phase 1
Active, not recruiting NCT04976699 - CD24Fc for the Prevention of Acute Graft Versus Host Disease (GVHD) Following Myeloablative Hematopoietic Stem Cell Transplantation (HSCT) (MK-7110-005) Phase 3
Terminated NCT04095858 - Efprezimod Alfa (CD24Fc, MK-7110) for the Prevention of Acute Graft Versus Host Disease (GVHD) Following Myeloablative Hematopoietic Stem Cell Transplantation (HSCT) (MK-7110-005) Phase 3
Completed NCT02359929 - BMT Autologous MSCs for GvHD Phase 1
Withdrawn NCT00640497 - Anti-CD3 & Anti-CD7 Ricin A Immunotoxin-Combination for Acute Graft Versus Host Disease Phase 1/Phase 2
Completed NCT03491215 - Study of Pharmacokinetics, Activity and Safety of Ruxolitinib in Pediatric Patients With Grade II-IV Acute Graft vs. Host Disease Phase 1/Phase 2
Completed NCT02687646 - Clinical Trial With MSC for Graft Versus Host Disease Treatment Phase 1/Phase 2