Bacteriological Study of Acute Follicular Tonsillitis

Acute Follicular Tonsillitis Clinical Trial

Official title:

Bacteriological Study of Acute Follicular Tonsillitis in Patients Attending the ENT Outpatient Clinic of Assiut University Hospital

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT04321733
• Other study ID #: Bacteriology of Tonsillitis
• Status: Not yet recruiting
• Start date: April 2020
• Est. completion date: October 2021

Study information

• Verified date: March 2020
• Source: Assiut University
• Contact: Mena W Dous, Principal investigator
• Phone: +201277170022
• Email: Dr_manoon[@]hotmail.com
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

The objective of the study is to answer the following questions :-

1. Is there an actual failure rate in tonsillitis treatment with amoxicillin clavulanate ? If yes,

2. What is (are) the possible reason(s) to explain it in our locality ?

Description:

Tonsillitis is one of the most common diseases in the throat that occurs in the younger age group .

The predominant bacteria causing tonsillitis are group A b-haemolytic streptococci (GABHS), which are highly susceptible to the penicillin group of antibiotics.

It has been reported in the literature that the rate of penicillin failure has consistently increased from about 7% in the 1950s to almost 40% in the 2000s.

Authors propose many reasons to explain such failure rates e.g. the coexistence of oropharyngeal beta-lactamase producing bacteria .

Although there were no documented reports, it was observed that there are rising reports of failure in treatment of acute follicular tonsillitis by amoxicillin clavulanate.

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 66
• Est. completion date: October 2021
• Est. primary completion date: April 2021
• Accepts healthy volunteers: No
• Gender: All
• Age group: 5 Years to 60 Years

Eligibility

Inclusion criteria:

patients with acute follicular tonsillitis neither younger than five years nor older than 60 years old.

Exclusion Criteria:

1. Other causes of tonsillitis that do not cause suppuration .

2. Age below five , and above 60 years .

3. Patients who received antibiotic one week before presentation .

4. Immune compromised patients .

5. Patients with quinsy.

Related Conditions & MeSH terms

• Acute Follicular Tonsillitis
• Tonsillitis

Intervention

Drug:
• Amoxicillin Clavulanate
Intravenous drug intake of our drug.

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Assiut University

References & Publications (3)

Brook I. Overcoming penicillin failures in the treatment of Group A streptococcal pharyngo-tonsillitis. Int J Pediatr Otorhinolaryngol. 2007 Oct;71(10):1501-8. Epub 2007 Jul 17. Review. — View Citation

Casey JR, Pichichero ME. The evidence base for cephalosporin superiority over penicillin in streptococcal pharyngitis. Diagn Microbiol Infect Dis. 2007 Mar;57(3 Suppl):39S-45S. Epub 2007 Feb 9. Review. — View Citation

Sela S, Barzilai A. Why do we fail with penicillin in the treatment of group A streptococcus infections? Ann Med. 1999 Oct;31(5):303-7. Review. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	The sensitivity of the isolated organism to amoxicillin clavulanate according to culture and sensitivity test	throat swabs that will be taken from the tonsillar exudate, placed in sterile bottles and brought to the laboratory for Bacteriological culture of the organism and Antibiotic sensitivity tests will be done for the isolated organism(s).	Baseline

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