Urgent (<24 Hours) Versus Early (24 to 48 Hours) ERCP for Patients With Mild and Moderate Acute Cholangitis

Acute Cholangitis Clinical Trial

Official title: Urgent (<24 Hours) Versus Early (24 to 48 Hours) ERCP for Patients With Mild and Moderate Acute Cholangitis

Status Recruiting

Clinical Trial Summary

Acute Cholangitis is an emergency associated with significant morbidity and mortality which require prompt recognition and treatment. The decompression of biliary tree along with antibiotics are mainstay of therapy. Randomized comparative studies showed that ERCP achieves biliary decompression with markedly less morbidity and mortality compared with surgery, regardless of clinical drainage. Percutaneous trans hepatic drainage (PTBD) can be alternative to endoscopic drainage in selected group especially advanced hilar strictures and patients who are unfit for endoscopic procedure. Recent ASGE guidelines suggested the performance of ERCP within 48 hours for patients with acute cholangitis; however it is conditional recommendation with very low quality of evidence. Till date, no randomized trial has compared urgent ERCP versus early ERCP for acute cholangitis.

Clinical Trial Description

n/a

Related Conditions & MeSH terms

• Acute Cholangitis
• Cholangitis

• NCT number: NCT05920954
• Study type: Interventional
• Source: Asian Institute of Gastroenterology, India
• Contact: Hardik Rughwani, MD, DM
• Phone: 9426928600
• Email: hardik.hr@gmail.com
• Status: Recruiting
• Phase: N/A
• Start date: June 30, 2023
• Completion date: March 15, 2025