Acute Agitated Patients Clinical Trial
Official title:
Comparison Between Midazolam and Loxapine in the Treatment of Agitated Patients in the Emergency Department
Neuroleptics are used since a long time in the management of severely agitated patients.
Loxapine is routinely used in our country, with, to our knowledge no severe adverse event
reported, in this indication.
However, recently, benzodiazepines have appeared interesting in agitated patients, with the
use of midazolam.
The aim of this study is to compare midazolam to loxapine in the treatment of severe
agitated patients admitted in the emergency department.
Prospective, Randomized, Double-blind, Multicenter study (20 french emergency departments) ;
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Caregiver, Outcomes Assessor), Primary Purpose: Treatment