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Clinical Trial Summary

The investigators hypothesize that large doses of fluids used during intraoperative could affect lung parenchyma structure and, consequently, gas exchange and respiratory mechanics. The purpose of this study is to evaluate fluids effects on oxygenation, respiratory mechanics, by using two different solutions: crystalloid or colloid.


Clinical Trial Description

Inclusion Criteria:

- patients undergoing elective abdominal, thoracic, vascular surgery

- minimum age 18 years

- informed consent

Exclusion Criteria:

- patients with severe cardiomyopathy or severe heart failure

- history of coagulation disorders

- patients with severe cardiovascular or respiratory disorders

- renal insufficiency

Respiratory mechanic parameters (i.e., inspiratory peak pressure, plateau pressure, total airway resistance, and static compliance) are obtained .Blood samples are drawn simultaneously from the arterial catheters for gas analysis. Data were collected after induction of anesthesia (T0) after 1 h (T1), 2 h (T2), 3 h (T3) and at the end of surgery.

Primary outcome: evaluate the fluids effects on oxygenation, respiratory mechanics

Secondary outcome: Incidence of surgery related complications ;


Study Design

Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator, Outcomes Assessor), Primary Purpose: Health Services Research


Related Conditions & MeSH terms


NCT number NCT02071524
Study type Interventional
Source Università degli Studi di Ferrara
Contact Savino Spadaro, researcher
Phone +390532206570
Email spdsvn@unife.it
Status Recruiting
Phase N/A
Start date September 2013
Completion date April 2017

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